Leptin is not involved in the pathophysiology of endometriosis-related infertility

Iwona Wertel, Gogacz M, Marek Gogacz, Polak G, Grzegorz Polak, Jerzy Jakowicki, J Jakowicki, Jakowicki J, Kotarski J, Jan Kotarski
European journal of obstetrics, gynecology, and reproductive biology · 2004 · vol. 119(2) , pp. 206–209 · doi:10.1016/j.ejogrb.2004.08.004 · PMID:15808381 · W2080607732
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⚙ AI-generated summary by claude@2026-06, 2026-06-15 ⓘ

This study investigated the role of leptin in endometriosis-related infertility but found no evidence of its involvement in the condition's pathophysiology.

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Abstract

ObjectiveChanges in peritoneal fluid (PF) composition may affect fertilization as well as early embryonic development. Leptin, an adipocyte hormone, has been shown to act as a link between adipose tissue and the reproductive system. Therefore, we decided to assess peritoneal and serum leptin levels in infertile endometriotic patients.PatientsSeventy-two women were studied, including 30 fertile and 18 infertile women with ovarian endometriotic cysts and, as a reference group, 24 patients with unexplained infertility.ResultsNo significant difference in the peritoneal and leptin levels was found between the studied groups. Significantly higher PF leptin concentration was observed in patients with stages III and IV of endometriosis as compared to those with minimal stage of the disease. In fertile patients with endometriosis a positive correlation has been found between PF and serum leptin concentrations.ConclusionsNo differences in peritoneal or serum leptin levels between infertile and fertile women with endometriosis suggest that this cytokine is not involved in pathophysiology of endometriosis-related infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Leptin Adolescent Adult Ascitic Fluid Ascitic Fluid Endometriosis Female Humans Infertility, Female Leptin Leptin Leptin

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (14)

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