Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways

Hoon Kyu Oh, H. K. Oh, Youn Seok Choi, Y Yang, Yeong-In Yang, Ji‐Hoon Kim, Ji-Hyun Kim, Peter C K Leung, Jung‐Hye Choi, Jung-Hye Choi
Molecular human reproduction · 2012 · vol. 19(3) , pp. 160–168 · doi:10.1093/molehr/gas055 · PMID:23184927 · W2129708652
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Leptin receptor is upregulated in endometriosis, and leptin stimulates endometriotic epithelial cell growth via JAK2/STAT3 and ERK activation.

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Abstract

Leptin acts as a potential growth stimulator in several normal and neoplastic cells. Recent studies have shown the presence of increased levels of leptin in the peritoneal fluid of patients with endometriosis, implicating leptin in the pathogenesis of endometriosis. However, the specific function of leptin in the induction of mitogenesis in endometriosis is not known. This study investigated the expression of the leptin receptor (ObR) in endometrioma tissues and immortalized endometriotic cells, and the effect of leptin on cell growth. ObR expression was higher in endometriomas than in the normal endometrium, and it was detected in 74% of epithelial and 30% of stromal endometrioma tissues. In addition, human endometriotic epithelial cells (11Z and 12Z) showed a high level of ObR when compared with endometrial cells and endometriotic stromal cells (22B). Furthermore, leptin treatment stimulated the growth of 11Z and 12Z cells, but not that of 22B cells. Knockdown of the ObR in 11Z and 12Z cells impaired the ability of leptin to induce cell growth. Leptin induced the activation of Janus Kinases 2 (JAK2), signal transducers and activators of transcription 3 (STAT3) and extracellular signal-regulated kinase (ERK) in endometriotic epithelial cells. Moreover, pretreatment with the JAK2/STAT3 inhibitor AG490 and the ERK inhibitor PD98059 significantly inhibited leptin-induced cell growth. The present results show that the ObR is induced in endometriosis, and that leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Janus Kinase 2 Receptors, Leptin STAT3 Transcription Factor Adult Cell Proliferation Cell Proliferation Cells, Cultured Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Enzyme Inhibitors Enzyme Inhibitors Epithelial Cells Epithelial Cells Epithelial Cells Epithelial Cells

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