Expression of adiponectin, leptin, and their receptors in ovarian endometrioma

Youn Seok Choi, Choi YS, Hoon Kyu Oh, Oh HK, Jung-Hye Choi, Choi JH, Jung‐Hye Choi
Fertility and sterility · 2013 · vol. 100(1) , pp. 135–141.e2 · doi:10.1016/j.fertnstert.2013.03.019 · PMID:23579009 · W2080729341
Other OA: bronze CC0 ⤵ 15 in-corpus citations
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This study investigated the presence and levels of adiponectin, leptin, and their corresponding receptors within ovarian endometrioma tissue.

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Abstract

OBJECTIVE: To evaluate the expression of leptin, leptin receptor (ObR), adiponectin, and adiponectin receptor (AdipoR) in ovarian endometriomas compared with normal endometrium, and to analyze relationships among adipokines and their receptors. DESIGN: Experimental study. SETTING: A clinic for the treatment of endometriosis and basic research laboratories. PATIENT(S): Forty-four women with endometriosis and 42 age-matched women with no laparoscopic evidence of endometriosis as control subjects. INTERVENTION(S): Endometrial tissue samples were obtained during laparoscopic surgery. MAIN OUTCOME MEASURE(S): Immunohistochemical staining for leptin, ObR, adiponectin, and AdipoR was performed with the use of tissue microarray. Clinical characteristics were reviewed from the patient's medical records. The effect of leptin on the expression of adiponectin was evaluated in endometriotic cell line using real-time reverse-transcription polymerase chain reaction. RESULT(S): Positive expression rates of leptin and ObR were significantly higher in ovarian endometrioma compared with normal endometrium, but those of adiponectin and AdipoR were similar (ovarian endometrioma vs. normal endometrium, respectively: leptin 100% vs. 59.5%; ObR 72.7% vs. 33.3%; adiponectin 31.8% vs. 42.9%; AdipoR 88.6% vs. 73.8%). Expression of adipokines and their receptors did not show any correlation with disease stage. A positive correlation was found between expression of ObR and adiponectin (correlation coefficient 0.488; P=.001). Leptin treatment in endometriotic cells induced mRNA expression of adiponectin. CONCLUSION(S): These data suggest that leptin and its receptor are induced in ovarian endometriomas, and that the leptin/ObR system regulates adiponectin gene expression in endometriotic cells.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Adiponectin Endometriosis Leptin Ovary Receptors, Adiponectin Receptors, Leptin Adiponectin Adiponectin Adult Adult Biomarkers Biomarkers Biomarkers Cell Line, Transformed Cell Line, Transformed Endometriosis Endometriosis Endometriosis Female Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (16)

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