Analysis of Changes in Serum Levels and Gene Expression Profiles of Novel Adipocytokines (Omentin, Vaspin, Irisin and Visfatin) and Their Correlation with Serum C-reactive Protein Levels in Women Diagnosed with Endometriosis

Ecem Kaya‐Sezginer, Omer Faruk Kırlangıç, Merve Didem Eşkin Tanrıverdi, Hasan Onur Topçu, Serap Gür
Turkish journal of pharmaceutical sciences · 2021 · vol. 19(1) , pp. 48–53 · doi:10.4274/tjps.galenos.2021.52284 · PMID:35227049 · W3159074751
article OA: diamond CC0 ⤵ 6 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found elevated serum irisin and C-reactive protein levels, alongside reduced visfatin and vaspin gene expression, in women with endometriosis, suggesting potential biomarker roles.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated whether novel adipocytokines (omentin, vaspin, irisin, and visfatin) differ between 16 women diagnosed with endometriosis and 14 ultrasound-confirmed healthy controls, and whether they correlate with serum C-reactive protein (CRP). Serum omentin, vaspin, and irisin were measured by ELISA, CRP was measured in serum, and visfatin and vaspin gene expression were assessed in whole blood using real-time PCR. The main findings were that serum irisin and CRP were significantly higher in endometriosis, irisin positively correlated with BMI and CRP, and visfatin and vaspin mRNA expression were significantly lower in endometriosis; there were no significant differences in serum omentin and vaspin protein levels. The paper notes limitations including small sample size and the need for larger studies to clarify mechanisms and establish prognostic/biomarker value. This paper is centrally about endometriosis—specifically measuring adipocytokines (including irisin, visfatin, vaspin, and omentin) and relating them to CRP and inflammation-associated gene expression in endometriosis patients.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objectives: This study aimed to investigate the role of new adipocytokines (omentin, vaspin, irisin and visfatin) in the development of endometriosis and the relationship of these adipocytokines with the inflammatory marker, C-reactive protein (CRP) levels in serum. Materials and Methods: ultrasound. Serum omentin, vaspin and irisin levels were measured by ELISA method. CRP levels in serum and the gene expression of visfatin and vaspin in whole blood samples were determined by clinical analyzer and the real-time polymerase chain reaction, respectively. Results: Serum irisin and CRP levels in the endometriosis group were significantly higher than in the control group. Irisin protein levels demonstrated a positive correlation with body mass index and CRP in women diagnosed with endometriosis. No statistically significant difference was found in serum omentin and vaspin levels between groups. The visfatin and vaspin gene expression in whole blood samples from the endometriosis group was found to be significantly lower than the control group. Conclusion: Increased levels of serum irisin and decreased visfatin and vaspin gene expressions in blood may be considered as a potential biomarker in endometriosis. The identification of new adipocytokines, which demonstrate an alteration in the presence of endometriosis and the relationship between these adipocytokines and inflammation will facilitate the detection of mechanisms involved in endometriosis and will lead to the development of targeted therapy.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (6)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:23:57.700195+00:00
License: CC0 · commercial use OK