Personalized approach to infertility treatment in endometriosis: results of a prospective cohort study

Seda Uvaysovna Imieva, Maria Andreevna Manuilova, Akhmed Gasainaevich Vagidov, Gadzhimurad Magomedovich Magomedov, Rayana Skandarbekowna Yunusova, Svetlana Sergeevna Poleeva, Magomed Bashirovich Zugunov, Mikail Akhmedovich Makhmudov
In: Journal of Advanced Pharmacy Education and Research · 2025 · vol. 15(1) , pp. 124–132 · doi:10.51847/fuljkafcfs · W4412812258
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

A prospective cohort study found that a combined surgical and conservative therapy approach for endometriosis yielded a higher pregnancy rate (57.5%) compared to surgery alone (35.0%) or conservative therapy alone (22.5%).

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text ⓘ

This prospective cohort study evaluated infertility outcomes in 120 reproductive-age women with confirmed endometriosis, comparing three treatment strategies: surgical (n=40), conservative therapy (n=40), and a combined approach using assisted reproductive technologies (n=40). Combination therapy showed a higher pregnancy rate (57.5%) than surgical (35.0%) or conservative treatment (22.5%), while endometrial thickness increased and systemic inflammation as measured by C-reactive protein decreased across all groups; quality-of-life improvement was greatest in the combined group. The paper reports that surgical treatment was more effective in stages I–II (41.7%) but was associated with reduced anti-Müllerian hormone levels (from 3.2±1.5 to 2.1±1.0 ng/ml), and it also emphasizes tailoring treatment to disease stage and ovarian reserve/reproductive status. This paper is centrally about endometriosis — it directly compares infertility treatment modalities and their effects on pregnancy, endometrial parameters, inflammation, ovarian reserve, and quality of life in women with endometriosis.

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Abstract

The present study evaluated the effectiveness of various endometriosis treatment methods in restoring fertility in 120 women of reproductive age with a confirmed diagnosis. The patients were divided into three groups: surgical treatment (n=40), conservative therapy (n=40), and a combined approach (n=40). The results showed the advantage of combination therapy with a pregnancy rate of 57.5% versus 35.0% for surgical and 22.5% for conservative treatment. The surgical method demonstrated efficacy i
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Abstract

The present study evaluated the effectiveness of various endometriosis treatment methods in restoring fertility in 120 women of reproductive age with a confirmed diagnosis. The patients were divided into three groups: surgical treatment (n=40), conservative therapy (n=40), and a combined approach (n=40). The results showed the advantage of combination therapy with a pregnancy rate of 57.5% versus 35.0% for surgical and 22.5% for conservative treatment. The surgical method demonstrated efficacy in stages I-II (41.7%), but was accompanied by a decrease in the level of anti-Muller hormone from 3.2±1.5 to 2.1±1.0 ng/ml. In all groups, there was an improvement in endometrial parameters (thickness increased from 6.1±1.2 to 7.8±1.4 mm) and a decrease in systemic inflammation (C-reactive protein decreased from 8.2±3.1 to 3.5±1.8 mg/l). The greatest improvement in the quality of life was recorded in the combined group (a decrease in the scores of the Endometriosis Health Profile questionnaire-30 from 68.2±12.4 to 28.7±8.3). The information gathered demonstrates that the best course of action is combined therapy with assisted reproductive technologies, particularly during phases III–IV, while surgical treatment may be the method of choice in the early stages in patients with preserved ovarian reserve, which justifies the need for a personalized approach taking into account the stage of the disease and the reproductive status of the patient.

Keywords

Endometriosis, Infertility, Fertility, Surgical treatment, Combination therapy, Assisted reproductive technologies How to cite this article: Citation Formats: Contact Meral Meral Publications www.meralpublisher.com Davutpasa / Zeytinburnu 34087 Istanbul Turkey Email: [email protected]

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Outcome instruments

EHP-30

Condition tags

endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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