Obesity and Endometriosis

In: Obesity and its Impact on Health · 2021 · pp. 49–58 · doi:10.1007/978-981-33-6408-0_4 · W3131587786
book-chapter OA: closed CC0
Full text JSON View on OpenAlex View at publisher
AI-generated summary by claude@2026-06+body, 2026-06-11

This book chapter explains whether obesity is linked to endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-11 · read from full text

This paper/chapter examines whether obesity is linked to endometriosis, describing obesity epidemiology and potential mechanisms such as adipokines, inflammation, and genetic and lifestyle factors using evidence from the literature. It notes that women of reproductive age are disproportionately affected by obesity and that obesity is associated with increased healthcare costs and related diseases (e.g., diabetes and hypertension), while discussing adipokines relevant to endometriosis biology. A major caveat is that the chapter is not an original study; it synthesizes prior findings without providing new primary data or a definitive causal estimate. Relevance to endometriosis: the chapter’s stated purpose is to explain whether obesity is linked to endometriosis, positioning adipokine and obesity-related pathways as potential contributors, though it is also framed within a broader overview of obesity and health impacts. This paper is centrally about endometriosis — it is a chapter specifically addressing the obesity–endometriosis connection.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Full text 10,638 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Malaysia has been noted to have the most overweight and obese population among ASEAN countries. Not only in Malaysia, other countries too faced the same conundrum of obesity. Increasing affluence in the population, rapid urbanisation, an increasingly sedentary lifestyle and genetic aspects all influence obesity. Healthcare costs will increase because diseases such as diabetes mellitus (DM), hypertension and heart-related diseases will rise directly in proportion to obesity rates. Obesity is a commonly found phenomenon among women of the reproductive age. Twenty-six percent of women have a body mass index (BMI) of more than 30 kg/m2 in United Kingdom. There is a preponderance of women by up to three times among admissions to hospitals with a primary diagnosis of obesity. Three times as many female patients seek bariatric surgery as men. The preponderance of the females (up to 70%) will be in the childbearing age. A quarter of women presenting for bariatric surgery suffered from infertility in one study. This book chapter explains whether obesity is linked to endometriosis. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Ahn JH, Choi YS, Choi JH (2015) Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway. Mol Hum Reprod 21(10): 792-802 Backonja U, Buck Louis GM, Lauver DR (2016) Overall adiposity, adipose tissue distribution, and endometriosis: A systematic review. Nurs Res 65(2): 151-166 Baranov V, Malysheva O, Yarmolinskaya M (2018) Pathogenomics of endometriosis development. Int J Mol Sci 19(7): E1852 Bijen CB, de Bock GH, Vermeulen KM, Arts HJ, ter Brugge HG, van der Sijde R, Kraayenbrink AA, Bongers MY, van der Zee AG, Mourits MJ (2011) Laparoscopic hysterectomy is preferred over laparotomy in early endometrial cancer patients, however not cost effective in the very obese. Eur J Cancer 47(14): 2158-2165 Bohlouli S, Khazaei M, Teshfam M, Hassanpour H (2013) Adiponectin effect on the viability of human endometrial stromal cells and mRNA expression of adiponectin receptors. Int J Fertil Steril 7(1): 43-48 Cabrera de León A, Almeida González D, González Hernández A, Juan Alemán Sánchez J, Brito Díaz B, Domínguez Coello S, Marcelino Rodríguez I, Gregorio Oliva García J, Aguirre Jaime A, Rodríguez Pérez Mdel C (2014) The association of resistin with coronary disease in the general population J Atheroscler Thromb 21(3): 273-281 Cho SA, Joo HJ, Cho JY, Lee SH, Park JH, Hong SJ, Yu CW, Lim DS (2017) Visceral fat area and serum adiponectin level predict the development of metabolic syndrome in a community-based asymptomatic population. PLoS One 12(1): e0169289 Choi YS, Oh HK, Choi JH (2013) Expression of adiponectin, leptin, and their receptors in ovarian endometrioma. Fertil Steril 100(1): 135-141 Cymbaluk-Płoska A, Chudecka-Głaz A, Pius-Sadowska E, Sompolska-Rzechuła A, Machaliński B, Menkiszak J (2016) Association between resistin levels and cardiovascular disease events in older adults: the health, aging and body composition study. Atherosclerosis 245: 181-186 de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56(6): 1655-1661 Dobrzyn K, Smolinska N, Kiezun M, Szeszko K, Rytelewska E, Kisielewska K, Gudelska M, Kaminski T (2018) Adiponectin: A new regulator of female reproductive system. Int J Endocrinol 2018: 7965071 Dos Santos E, Serazin V, Morvan C, Torre A, Wainer R, de Mazancourt P, Dieudonné MN (2012) Adiponectin and leptin systems in human endometrium during window of implantation. Fertil Steril 97(3): 771-778 Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hhooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W (2014) ESHRE guideline: management of women with endometriosis. Hum Reprod 29(3): 400-412 Guerrero-García JJ, Carrera-Quintanar L, López-Roa RI, Márquez-Aguirre AL, Rojas-Mayorquín AE, Ortuño-Sahagún D (2016) Multiple sclerosis and obesity: Possible roles of adipokines. Mediators Inflamm 2016: 4036232 Friedman J (2016) The long road to leptin. J Clin Invest 126: 4727-4734 Foley K, Lee RB (1990) Surgical complications of obese patients with endometrial carcinoma. Gynecol Oncol 39(2): 171-174 Gonçalves HF, Zendron C, Cavalcante FS, Aiceles V, Oliveira MA, Manaia JH, Babinski MA, Ramos CF (2015) Leptin, its receptor and aromatase expression in deep infiltrating endometriosis. J Ovarian Res 8: 53 Haluzik and D. Haluzikova (2006) The role of resistin in obesity-induced insulin resistance. Current Opinion in Investigational Drugs 7(4): 306-311 Jasieńska G, Ziomkiewicz A, Ellison PT, Lipson SF, Thune I (2004) Large breasts and narrow waists indicate high reproductive potential in women. Proc Biol Sci 271(1545): 1213-1217 Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M (2005) Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97(12): 1245-1252 Li X, Yu Z, Fang L, Liu F, Jiang K (2017) Expression of adiponectin receptor-1 and prognosis of epithelial ovarian cancer patients. Med Sci Monit 23: 1514-1521 Liu Y, Zhang W (2017) Association between body mass index and endometriosis risk: a meta-analysis. Oncotarget 8(29): 46928-46936 Malhotra N, Karmakar D, Tripathi V, Luthra K, Kumar S (2011) Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. Gynecol Endocrinol 28(3): 224-247 Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, Tilg H. Visfatin (2007) An adipocytokine with proinflammatory and immunomodulating properties. J Immunol 178(3): 1748-1758 Mowers EL, Lim CS, Skinner B, Mahnert N, Kamdar N, Morgan DM, As-Sanie S (2016) Prevalence of endometriosis during abdominal or laparoscopic hysterectomy for chronic pelvic pain. Obstet Gynecol 127(6): 1045 Nieva-Vazquez A, Pérez-Fuentes R, Torres-Rasgado E, López-López JG, Romero JR (2014) Serum resistin levels are associated with adiposity and insulin sensitivity in obese Hispanic subjects. Metab Syndr Relat Disord 12(2): 143-148 Oh HK, Choi YS, Yang YI, Kim JH, Leung PC, Choi JH (2013) Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. Mol Hum Reprod 19(3): 160-168 Oh YK, Ha YR, Yi KW, Park HT, Shin JH, Kim T, Hur JY (2017) Increased expression of resistin in ectopic endometrial tissue of women with endometriosis. Am J Reprod Immunol 78(5): 12726 Otani K, Ishihara S, Yamaguchi H, Murono K, Yasuda K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H, Watanabe T (2017) Adiponectin and colorectal cancer. Surg Today 47(2): 151-158 Pandey N, Kriplani A, Yadav RK, Lyngdoh BT, Mahapatra SC (2010) Peritoneal fluid leptin levels are increased but adiponectin levels are not changed in infertile patients with pelvic endometriosis. Gynecol Endocrinol 26(11): 843-849 Scotece M, Pérez T, Conde J, Abella V, López V, Pino J, Gonzalez-Gay MA, Gomez-Reino JJ, Mera A, Gomez R, Gualillo O (2017) Adipokines induce pro-inflammatory factors in activated Cd4+ T cells from osteoarthritis patient. J Orthop Res 35(6): 1299-1303 Schuler KM, Rambally BS, DiFurio MJ, Sampey BP, Gehrig PA, Makowski L, Bae-Jump VL (2015) Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer. Cancer Med 4(2): 161-173 Shah NR, Braverman ER (2012) Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin. PLoS One 7(4): e33308 Shaw KA, O’Rourke P, Del Mar C, Kenardy J (2005) Psychological interventions for overweight or obesity. Cochrane Database Syst Rev (2): CD003818 Takemura Y, Osuga Y, Harada M, Hirata T, Koga K, Yoshino O, Hirota Y, Morimoto C, Yano T, Taketani Y (2005) Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis. Am J Reprod Immunol 54(4): 217-221 Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T, Morimoto C, Hirota Y, Yoshino O, Koga K, Yano T, Kadowaki T, Taketani Y (2006) Expression of adiponectin receptors and its possible implication in the human endometrium. Endocrinol 147(7): 3203-3210 Thomas D, Apovian C (2017) Macrophage functions in lean and obese adipose tissue. Metabolism 72: 120-143 Tworoger SS, Huang T (2016) Obesity and ovarian cancer. Recent Results Cancer Res 208: 155-176 van Harmelen V, Reynisdottir S, Eriksson P, Thörne A, Hoffstedt J, Lönnqvist F, Arner P (1998) Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 47(6): 913-917 Vegiopoulos A, Rohm M, Herzig S (2017) Adipose tissue: between the extremes. EMBO J 36(14): 1999-2017 von Gruenigen VE, Tian C, Frasure H, Waggoner S, Keys H, Barakat RR (2006) Treatment effects, disease recurrence, and survival in obese women with early endometrial carcinoma: a Gynecologic Oncology Group study. Cancer 107(12): 2786-2791 Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action Am J Physiol Endocrinol Metab 290(6): E1253-1261 Yi KW, Shin JH, Park HT, Kim T, Kim SH, Hur JY (2010) Resistin concentration is increased in the peritoneal fluid of women with endometriosis. Am J Reprod Immunol 64(5): 318-323 Zhang QF, Chen GY, Liu Y, Huang HJ, Song YF (2017) Relationship between resistin and IL-23 levels in follicular fluid in infertile patients with endometriosis undergoing IVF-ET. Adv Clin Exp Med 26(9): 1431-1435 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2021 Springer Nature Singapore Pte Ltd. About this chapter Cite this chapter Jegasothy, R., Abdalla, M.M.I., Elengoe, A., Kutty, M.K. (2021). Obesity and Endometriosis. In: Kutty, M.K., Elengoe, A. (eds) Obesity and its Impact on Health. Springer, Singapore. https://doi.org/10.1007/978-981-33-6408-0_4 Download citation DOI: https://doi.org/10.1007/978-981-33-6408-0_4 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-33-6407-3 Online ISBN: 978-981-33-6408-0 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (46)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK