Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis

X Zhang, P Hei, Peter Hei�, Lin Deng, L Deng, J Lin, Jun Lin
Molecular human reproduction · 2006 · vol. 13(2) , pp. 135–140 · doi:10.1093/molehr/gal106 · PMID:17178764 · W2153394923
article OA: closed CC0 ⤵ 26 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found increased frequency of IL-10 gene promoter polymorphisms at -819 or -592 and higher IL-10 protein levels in peritoneal fluid of endometriosis patients compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Although associations of interleukin-10 (IL-10) gene promoter polymorphisms and their protein production with endometriosis risk have been reported, the correlations remain controversial. The objective of this study was to determine IL-10 gene promoter polymorphisms at -1082, -819 and -592 sites and their protein production in peritoneal fluid (PF) in patients with and without endometriosis. IL-10 gene promoter polymorphisms at -1082 site were detected by amplification refractory mutation system (ARMS)-PCR and that at -819 and -592 sites was genotyped by restriction fragment length polymorphism (RFLP)-PCR. Protein levels of IL-10 in PF were measured by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in the genotype and allele frequencies of IL-10 gene promoter polymorphisms at position -1082 between the endometriosis and the control groups. However, the frequency of -819 or -592 C alleles was significantly increased in patients with endometriosis compared with controls. The protein levels of IL-10 in PF were statistically higher in the endometriosis group than in the control group. Moreover, the polymorphisms at -1082, -819 and -592 sites were associated with protein levels of IL-10 in PF in the endometriosis group while in the control group only the polymorphisms at position -1082 correlated with protein levels. Increased frequency of -819 or -592 C allele and increased protein production of IL-10 in PF in patients with endometriosis compared with controls and correlations of polymorphisms at -819 and -592 sites with protein levels of IL-10 in PF in patients with endometriosis may suggest that polymorphisms at -819 and -592 sites and their protein production are associated with endometriosis risk.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometriosis Interleukin-10 Interleukin-10 Promoter Regions, Genetic Ascitic Fluid Ascitic Fluid Disease Progression Endometriosis Endometriosis Female Gene Frequency Haplotypes Humans Interleukin-10 Polymorphism, Single Nucleotide

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (26)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:06.633332+00:00
License: CC0 · commercial use OK