Cyclooxygenase‐2 (COX‐2) Gene‐765G/C Polymorphism and Advanced‐Stage Endometriosis in Korean Women

Hye Yeon Kim, Sihyun Cho, Young Sik Choi, Hyo In Yang, Kyung Eun Lee, Seok Kyo Seo, Byung Seok Lee
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 68(3) , pp. 238–243 · doi:10.1111/j.1600-0897.2012.01151.x · PMID:22587873 · W2008615261
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the COX-2 gene-765G/C polymorphism in Korean women and found the -765C allele was associated with a significantly lower risk of advanced-stage endometriosis.

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Abstract

PROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.

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Condition tags

endometriosis

MeSH descriptors

Asian People Cyclooxygenase 2 Endometriosis Endometrium Polymorphism, Single Nucleotide Adolescent Adult Alleles Case-Control Studies Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Frequency Genetic Predisposition to Disease Haplotypes Humans

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References (37)

Cited by (7)

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noordeloos 2009062

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