Cyclooxygenase‐2 (COX‐2) Gene‐765G/C Polymorphism and Advanced‐Stage Endometriosis in Korean Women

Hye Yeon Kim, Kim HY, SiHyun Cho, Young Sik Choi, Yang HI, Hyo In Yang, Lee KE, Kyung Eun Lee, Seok Kyo Seo, Lee BS, Byung Seok Lee
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 68(3) , pp. 238–243 · doi:10.1111/j.1600-0897.2012.01151.x · PMID:22587873 · W2008615261
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This study investigated the COX-2 gene-765G/C polymorphism in Korean women and found the -765C allele was associated with a significantly lower risk of advanced-stage endometriosis.

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Abstract

PROBLEM: We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women. METHOD OF STUDY: This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis. RESULTS: There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30). CONCLUSIONS: We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.

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Condition tags

endometriosis

MeSH descriptors

Asian People Cyclooxygenase 2 Endometriosis Endometrium Polymorphism, Single Nucleotide Adolescent Adult Alleles Case-Control Studies Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Frequency Genetic Predisposition to Disease Haplotypes Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (37)

Cited by (7)

SciLite annotations

organisms 1
noordeloos 2009062

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