Clinical relevance of the baboon as a model for the study of endometriosis

D'Hooghe TM, Thomas D’Hooghe, T M D'Hooghe
Fertility and sterility · 1997 · vol. 68(4) , pp. 613–625 · doi:10.1016/s0015-0282(97)00277-x · PMID:9341599 · W2119678610
review OA: bronze CC0 ⤵ 100 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper reviews the clinical relevance of baboons as an animal model for studying endometriosis, detailing anatomical and physiological similarities to humans.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo review the value of the baboon as a model for the study of endometriosis.Data identification and selectionStudies performed at the Institute of Primate Research in Nairobi, Kenya (1990-1994), and published in peer-reviewed journals.Result(s)Spontaneous endometriosis was found in about 25% of the baboons, and its prevalence increased with the duration of captivity. The laparoscopic appearance, pelvic localization, and microscopic aspects of the disease were similar to endometriosis in women. Microscopic endometriosis in macroscopically normal peritoneum was rare. Sampson's hypothesis (i.e., retrograde menstruation causes endometriosis) was supported by the increased incidence of retrograde menstruation in baboons with spontaneous endometriosis, the observation that cervical occlusion could cause retrograde menstruation and endometriosis, and the finding that intrapelvic injection of menstrual endometrium caused experimental moderate to severe endometriosis similar to the spontaneous disease. During follow-up of more than 2 years, endometriosis in baboons appeared to be a progressive disease, with active remodeling between several types of lesions. Progression was stimulated by high-dose immunosuppression. Fertility was normal in baboons with minimal disease but was reduced in baboons with mild, moderate, or severe endometriosis, possibly related to an increased incidence and recurrence of the luteinized unruptured follicle syndrome.Conclusion(s)The baboon is a good model for the study of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Papio Animals Disease Models, Animal Disease Progression Endometriosis Endometriosis Female Fertility Humans Papio Prevalence

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

europepmc
last seen: 2026-08-19T06:08:28.815611+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:46.468712+00:00
License: CC0 · commercial use OK