Development of spontaneous endometriosis in baboons

T M D'Hooghe, Thomas D’Hooghe, D'Hooghe TM, Bambra CS, Charanjit S. Bambra, C S Bambra, Raeymaekers BM, B RAEYMAEKERS, B M Raeymaekers, Koninckx PR, Philippe R. Koninckx, P R Koninckx
Obstetrics and gynecology · 1996 · vol. 88(3) , pp. 462–466 · doi:10.1016/0029-7844(96)00205-0 · PMID:8752259 · W1978325108
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This observational study found a 64% cumulative incidence of minimal endometriosis in baboons over 32 months, increasing with follow-up time and repeat laparoscopies.

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Abstract

OBJECTIVE: To determine the incidence of spontaneous endometriosis over a 32-month period in baboons with initially normal pelves. METHODS: In this observational longitudinal study, which was performed at the Institute of Primate Research, Nairobi (Kenya), 24 baboons with laparoscopically confirmed normal pelves underwent 67 serial laparoscopies (mean 2.8 +/- 1.9, median 3, range 1-6) after 1-3 months (n = 8), 4-6 months (n = 11), 7-9 months (n = 9), 10-12 months (n = 17), 13-15 months (n = 6), 16-18 months (n = 4), 19-21 months (n = 3), 22-24 months (n = 4), 25-27 months (n = 1), and 30-32 months (n = 4). During each laparoscopy, the pelvis was examined for the presence of endometriosis. The number, size, and type of endometriotic implants were noted on a pelvic map, and the endometriosis score and stage were tabulated according to the revised classification of the American Fertility Society. Taking into account the variable length of follow-up, we used life-table analysis to calculate the cumulative incidence of endometriosis. RESULTS: The cumulative incidence of minimal endometriosis (proven by histology) was 64% up to 32 months of follow-up. The eight baboons that developed proven endometriosis were followed over longer periods of time and had undergone more laparoscopies than the animals that did not develop the condition. CONCLUSION: There is a high incidence of minimal endometriosis in baboons, which increases with the time of follow-up and the number of repeat laparoscopies.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Monkey Diseases Papio Animals Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Incidence Laparoscopy Laparoscopy Life Tables Monkey Diseases Monkey Diseases Time Factors

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Cited by (31)

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