Baboon Model for Endometriosis

In: The Baboon in Biomedical Research · 2009 · pp. 139–156 · doi:10.1007/978-0-387-75991-3_7 · W37678202
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Endometriosis, characterized by ectopic endometrial tissue causing pain and infertility, remains poorly understood due to diagnostic and treatment limitations, prompting investigation into animal models.

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The paper describes endometriosis as an ectopic endometrial gland-and-stroma disorder associated with pelvic pain and infertility, while noting that pathogenesis, infertility mechanisms, and natural disease progression remain incompletely understood due to the need for invasive diagnosis and the tendency for recurrence after medical suppression or surgical excision. It reviews the development and rationale for using baboons as an experimental model, including prior work documenting spontaneous endometriosis prevalence, evolution over time, inflammatory changes, and experimental approaches such as inducing lesions by intrapelvic injection of menstrual endometrium and modeling retrograde menstruation. The paper highlights a major limitation inherent to the literature: most findings rely on model-specific induction and observational endpoints rather than direct clinical validation in humans. This paper is centrally about endometriosis — it focuses on establishing and characterizing a baboon model to study disease development, progression, and related mechanisms.

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References

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M., Dodson, M. G., Stephens, L. C., Buttram, V. C., Jr., Besch, P. K., and Kaufman, R. H. (1984). Transplantation of normal and ectopic human endometrial tissue into athymic nude mice. Am. J. Obstet. Gynecol. 149:591–597. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2009 Springer Science+Business Media, LLC About this chapter Cite this chapter D’Hooghe, T.M., Kyama, C.K., Mwenda, J.M. (2009). Baboon Model for Endometriosis. In: VandeBerg, J.L., Williams-Blangero, S., Tardif, S.D. (eds) The Baboon in Biomedical Research. Developments in Primatology: Progress and Prospects. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75991-3_7 Download citation DOI: https://doi.org/10.1007/978-0-387-75991-3_7 Publisher Name: Springer, New York, NY Print ISBN: 978-0-387-75990-6 Online ISBN: 978-0-387-75991-3 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

Keywords

- Peritoneal Fluid - Endometriotic Lesion - Early Luteal Phase - American Fertility Society - Retrograde Menstruation These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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