A serial section study of visually normal posterior pelvic peritoneum from baboons (Papio cynocephalus, Papio anubis) with and without spontaneous minimal endometriosis

T M D'Hooghe, D'Hooghe TM, Thomas D’Hooghe, Bambra CS, Charanjit S. Bambra, C S Bambra, Inge De Jonge, I De Jonge, De Jonge I, P N Machai, Peter N. Machai, Machai PN, Korir R, Richard Korir, R Korir, Philippe R. Koninckx, P R Koninckx, Koninckx PR
Fertility and sterility · 1995 · vol. 63(6) , pp. 1322–1325 · doi:10.1016/s0015-0282(16)57618-3 · PMID:7750607 · W2409875224
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This serial section study examined the posterior pelvic peritoneum of baboons, comparing specimens from animals with and without spontaneous minimal endometriosis to investigate underlying anatomical features.

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Abstract

ObjectivesTo determine if microscopic endometriosis exists in visually normal pelvic peritoneum from baboons with and without endometriosis.DesignObservational histologic study at Institute of Primate Research, Nairobi, Kenya.SubjectsSeventeen baboons including 13 adult females (5 with histologically proven endometriosis, 8 with a normal pelvis) and 4 juveniles (1 female and 3 males).InterventionsDiagnostic laparoscopy with identification of visually normal pelvic peritoneum before euthanasia, followed by laparotomy with excision of a large area (at least 4 x 6 cm or 24 cm2 per animal, 408 cm2 surface in all baboons) of this visually normal-appearing peritoneum.Main outcome measurePresence of microscopic endometriosis (endometrial glands and stroma) in serial sections of visually normal pelvic peritoneum.ResultsTwo adjacent glandular structures compatible with endometriosis were found in normal peritoneum obtained during menses from one female baboon without macroscopic disease. Microscopic endometriosis was not detected in the other female primates with or without macroscopic disease or in male animals.ConclusionMicroscopic endometriosis was found in only 1 of 14 female baboons (prevalence 7%; 95% confidence interval 0% to 33%) with visually normal pelvic peritoneum. These findings suggest that, with the paucity of human data available, more studies are needed before concluding that massive microscopic disease exists in visually normal-appearing peritoneum of women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Monkey Diseases Papio Peritoneum Animals Endometriosis Endometriosis Female Male Monkey Diseases Peritoneum

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