Production of fibronectin by peritoneal macrophages and concentration of fibronectin in peritoneal fluid from patients with or without endometriosis.
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Peritoneal macrophages from endometriosis patients produce three times more fibronectin in vitro, though their peritoneal fluid fibronectin concentration is 30% lower than in normal patients.
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Abstract
Fibronectin, a known growth factor for fibroblasts, is produced by alveolar macrophages from patients with interstitial pulmonary fibrosis. Because peritoneal macrophages have been implicated in the disease process of endometriosis, we measured the production of fibronectin by peritoneal macrophages in vitro and the concentration of fibronectin in peritoneal fluid samples. Twenty-nine patients had a normal pelvis, 22 had endometriosis, and 14 had tubal occlusion and/or adhesions. Human peritoneal macrophages demonstrated de novo synthesis of fibronectin. The peritoneal macrophage fibronectin was detected by an enzyme-linked immunosorbent assay for serum fibronectin. Peritoneal macrophages from patients with endometriosis produced approximately three times the amount of fibronectin as normal patients or patients with tubal occlusion and/or adhesions (P less than or equal to .01 and P less than or equal to .02, respectively). The mean peritoneal fluid concentration of fibronectin, however, was about 30% lower in patients with endometriosis than in normal patients (P less than or equal to .02). We suggest that increased peritoneal macrophage fibronectin production in patients with endometriosis may contribute to the adhesion formation and associated reactive fibrosis seen in this disease, and may also influence the implantation of endometrial cells and their subsequent growth in the pelvis.
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Cited by (43)
- The Double Engines and Single Checkpoint Theory of Endometriosis 2022
- Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis 2022
- The double engines and single checkpoint theory of endometriosis 2022
- Menstrual Effluent Provides a Novel Diagnostic Window on the Pathogenesis of Endometriosis 2020
- Diagnostic Performance of Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Endometrioma 2019
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- Die Wirkung von hCG auf die Dezidualisierung ektoper endometrialer Läsionen als therapeutischer Ansatz zur Behandlung der Endometriose 2014
- Endometriosis 2013
- Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis 2011
- Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis 2011
- Semi-invasive Diagnosis of Endometriosis Doctoral Thesis 2010
- Clinical Aspects of Endometriosis 2010
- Endometriosis 2009
- Baboon Model for Endometriosis 2009
- Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment 2008
- Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis 2007
- "Endometriose do trato gastrointestinal: correlações clínicas e laparoscópicas; papel da corrida dos órgãos peritoneais na endometriose (COPE)" 2005
- Serum and endometrial markers 2004
- Animal Models for Research on Endometriosis 2003
- Immunology of endometriosis 2002
- Theories of endometriosis 2001
- Immunobiology of endometriosis 2001
- Is endometriosis an endometrial disease? 2000
- 10.1016/s1047-9422(03)00073-7 2000
- Endometriosis, Endometrioma, and the Problem of Adhesions 2000
- Effects of peritoneal macrophages from women with endometriosis on endometrial cellular proliferation in an in vitro coculture model 1999
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Prognosis of Japanese Patients with Ovarian Clear Cell Carcinoma Associated with Pelvic Endometriosis: Clinicopathologic Evaluation 1999
- Endometriotic disease: the role of peritoneal fluid 1998
- Endometriosis-associated infertility 1997
- IMMUNOLOGY AND ENDOMETRIOSIS 1997
- Clinical relevance of the baboon as a model for the study of endometriosis 1997
- BASIC RESEARCH IN ENDOMETRIOSIS 1997
- The peritoneal environment in endometriosis 1996
- Immunological aspects of endometriosis 1996
- De novo formation of adhesions in endometriosis: the role of iron and free radical reactions 1995
- N-terminal truncated forms of insulin-like growth factor binding protein-3 in the peritoneal fluid of women without laparoscopic evidence of endometriosis 1995
- Monocyte-mediated enhancement of endometrial cell proliferation in women with endometriosis 1994
- 3 Endometriosis: The host response 1993
- Pathogenesis of endometriosis 1992
- The immune system in endometriosis 1991
- Effect of platelet-derived growth factor on endometrial stromal cell proliferation in vitro: a model for endometriosis? 1991
- Endometriosis as a Cause of Infertility 1989
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