Effect of platelet-derived growth factor on endometrial stromal cell proliferation in vitro: a model for endometriosis?
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Platelet-derived growth factor stimulates endometrial stromal cell proliferation in vitro, potentially modeling aspects of endometriosis.
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Abstract
ObjectiveTo assess the direct effects of platelet-derived growth factor (PDGF), a macrophage secretory product structurally and functionally similar to substances released by peritoneal macrophages isolated from endometriosis patients, on endometrial cell proliferation.DesignProspective analysis of cell proliferation in vitro.SettingProliferative phase endometrial stromal cells isolated from biopsy specimens were grown in short-term culture and served as a model for stromal components of endometriotic implants.PatientsBiopsies were obtained from regularly cycling volunteers without endometrial pathology.InterventionsPlatelet-derived growth factor was added to nutrient medium in both the presence and absence of suboptimal (2.5%) calf serum (CS) supplements and a physiological estradiol (E2) concentration (10(-9) M).Main outcome measuresCumulative [3H]-thymidine incorporation as a reflection of cell proliferation.ResultsPlatelet-derived growth factor exerted a significant dose-dependent effect on stromal cell proliferation in both the presence and absence of CS (P less than 0.01). This effect was enhanced in, at best, an additive but not synergistic manner by E2 10(-9) M.ConclusionThese data imply that macrophage secretory products such as PDGF may play a significant role in the maintenance or proliferation of endometriosis.
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- O inibidor Btk Ibrutinib limita o desenvolvimento da endometriose em camundongos 2021
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