Effect of platelet-derived growth factor on endometrial stromal cell proliferation in vitro: a model for endometriosis?
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Platelet-derived growth factor stimulates endometrial stromal cell proliferation in vitro, potentially modeling aspects of endometriosis.
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Abstract
OBJECTIVE: To assess the direct effects of platelet-derived growth factor (PDGF), a macrophage secretory product structurally and functionally similar to substances released by peritoneal macrophages isolated from endometriosis patients, on endometrial cell proliferation.
DESIGN: Prospective analysis of cell proliferation in vitro.
SETTING: Proliferative phase endometrial stromal cells isolated from biopsy specimens were grown in short-term culture and served as a model for stromal components of endometriotic implants.
PATIENTS: Biopsies were obtained from regularly cycling volunteers without endometrial pathology.
INTERVENTIONS: Platelet-derived growth factor was added to nutrient medium in both the presence and absence of suboptimal (2.5%) calf serum (CS) supplements and a physiological estradiol (E2) concentration (10(-9) M).
MAIN OUTCOME MEASURES: Cumulative [3H]-thymidine incorporation as a reflection of cell proliferation.
RESULTS: Platelet-derived growth factor exerted a significant dose-dependent effect on stromal cell proliferation in both the presence and absence of CS (P less than 0.01). This effect was enhanced in, at best, an additive but not synergistic manner by E2 10(-9) M.
CONCLUSION: These data imply that macrophage secretory products such as PDGF may play a significant role in the maintenance or proliferation of endometriosis.
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- Phytochemicals Modulating Receptor Tyrosine Kinase Signaling Networks in Endometriosis 2026
- Overview and Updates on the Role of Genetic Variants in Endometriosis Susceptibility and Pathogenesis 2026
- The Sphingosine 1-Phosphate Axis: an Emerging Therapeutic Opportunity for Endometriosis 2023
- The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis 2023
- O inibidor Btk Ibrutinib limita o desenvolvimento da endometriose em camundongos 2021
- Expression of nerve growth factor (NGF) in endometrium as a potential biomarker for endometriosis - Single tertiary care centre study 2020
- Osteopontin Regulates Endometrial Stromal Cell Migration in Endometriosis through the PI3K Pathway : Osteopontin Regulates Endometrial Cell Migration in Endometriosis 2020
- Immunomodulatory effects of vitamin D3 on gene expression of MDGF, EGF and PDGFB in endometriosis 2020
- Platelets induce endothelial-mesenchymal transition and subsequent fibrogenesis in endometriosis 2020
- Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition 2020
- In-vitro models of human endometriosis 2019
- Immunology of endometriosis 2018
- Is it possible to diagnose endometriosis at the level of endometrium? 2016
- A Critical Review of Endometriosis Pathology 2013
- Silencing Cofilin-1 blocks PDGF-induced proliferation in eutopic endometrium of endometriosis patients 2013
- Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility 2012
- Endometriosis: Disease Classification and Behavior 2011
- Genistein does not affect vascularization and blood perfusion of endometriotic lesions and ovarian follicles in dorsal skinfold chambers of Syrian golden hamsters 2010
- Silencing of cofilin-1 gene attenuates biological behaviours of stromal cells derived from eutopic endometria of women with endometriosis 2010
- Endometriose und Inflammation 2007
- Regulation of proliferation, motility, and contractility of human endometrial stromal cells by platelet-derived growth factor 2005
- Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions 2005
- Progesterone and progestational compounds attenuate tumor necrosis factor alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells 2005
- Effect of peroxisome proliferator-activated receptor-gamma agonist rosiglitazone on the induction of endometriosis in an experimental rat model 2005
- Endometriosis and inflammation in infertility 2004
- Endometriosis and inflammation in infertility 2004
- Angiogenic factors in endometriosis 2002
- Macrophages, oxidation, and endometriosis 2002
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- Peritoneal fluid cytokines and the relationship with endometriosis and pain 1996
- Peritoneal growth factors and endometriosis 1996
- N-terminal truncated forms of insulin-like growth factor binding protein-3 in the peritoneal fluid of women without laparoscopic evidence of endometriosis. Le groupe d'investigation en gynécologie 1995
- Leukocyte subpopulation changes in rats with autotransplanted endometrium and the effect of danazol 1995
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