Effect of peritoneal fluid from patients with mild and severe endometriosis on endometrial stromal cell proliferation
Peritoneal fluid from mild endometriosis stimulated stromal cell proliferation, while fluid from severe endometriosis inhibited it.
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This study evaluated the mitogenic effects of peritoneal fluid from women with mild versus severe endometriosis on the proliferation of primary human endometrial stromal cells. Increasing concentrations of peritoneal fluid from women without endometriosis and with mild (stage I) or severe (stage IV) endometriosis were added to stromal cell cultures, and DNA synthesis was quantified by 3H-thymidine incorporation. Peritoneal fluid from mild endometriosis induced a statistically significant dose-dependent increase in stromal cell thymidine uptake (about 5.8–14.5-fold), whereas peritoneal fluid from severe endometriosis led to an average 51% inhibition of proliferation compared with non-endometriosis peritoneal fluid or nutrient medium with 2.5% calf serum. The paper’s findings are limited to an in vitro culture system using peritoneal fluid, without confirming how these effects translate in vivo. This paper is centrally about endometriosis — it tests how peritoneal fluid from mild versus severe endometriosis differentially affects endometrial stromal cell proliferation.
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Cited by (11)
- Endocrine disruptor hexachlorobenzene induces cell migration and invasion, and enhances aromatase expression levels in human endometrial stromal cells 2022
- The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid 2020
- PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage 2019
- Enhanced cyclooxygenase-2 expression levels and metalloproteinase 2 and 9 activation by Hexachlorobenzene in human endometrial stromal cells 2016
- Regulación del crecimiento del tejido endometrial en respuesta a nuevas alternativas terapéuticas propuestas para tratar la endometriosis 2012
- P450Arom induction in isolated control endometrial cells by peritoneal fluid from women with endometriosis 2010
- Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression 2010
- Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis 2005
- Gonadotropin-releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis 2003
- Follicular fluid as a favourable environment for endometrial and endometriotic cell growth in vitro 2001
- Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis 2000
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