Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression
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Endometrial stromal cells cultured in peritoneal fluid from endometriosis patients showed increased proliferation and elevated COX-2 expression.
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Abstract
Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2) production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis.
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References (11)
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- Expression of Cyclooxygenase-2 in Eutopic Endometrium and Ovarian Endometriotic Tissue in Women with Severe Endometriosis via openalex
- P450Arom induction in isolated control endometrial cells by peritoneal fluid from women with endometriosis via openalex
- Up-Regulation of Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Human Endometriotic Cells by Macrophage Migration Inhibitory Factor: Involvement of Novel Kinase Signaling Pathways via openalex
- W2073541193 via openalex
- W2790805946 via openalex
Cited by (13)
- Bridging the gap: Exploring aspirin prophylaxis for preeclampsia prevention in pregnant women with endometriosis 2025
- Endometrial epithelial–mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia 2021
- PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells 2021
- The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid 2020
- Hematoendometrial conglomerate and changes to its microenvironment as the primary stage of formation of peritoneal endometriosis 2019
- Arrangement of myofibroblastic and smooth muscle-like cells in superficial peritoneal endometriosis and a possible role of transforming growth factor beta 1 (TGFβ1) in myofibroblastic metaplasia 2018
- The role of oxidation-sensitive nociception and epigenetics in endometriosis-associated pain 2017
- Redox regulation of microRNAs in endometriosis-associated pain 2017
- The Anti‐Inflammatory Impact of Omega‐3 Polyunsaturated Fatty Acids During the Establishment of Endometriosis‐Like Lesions 2014
- Possible effects of endometriosis-related immune events on reproductive function 2013
- Peritoneal Fluid Reduces Angiogenesis-Related MicroRNA Expression in Cell Cultures of Endometrial and Endometriotic Tissues from Women with Endometriosis 2013
- Antioxidant supplementation reduces endometriosis-related pelvic pain in humans 2012
- Role of prostaglandin E2 in bacterial growth in women with endometriosis 2012
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- europepmc
- last seen: 2026-08-10T06:11:17.106188+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:16:54.825375+00:00
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