The Anti‐Inflammatory Impact of Omega‐3 Polyunsaturated Fatty Acids During the Establishment of Endometriosis‐Like Lesions

Jill A Attaman, Jill Attaman, Aleksandar K Stanic, Minji Kim, Maureen P Lynch, Bo R Rueda, Aaron K Styer
American journal of reproductive immunology (New York, N.Y. : 1989) · 2014 · vol. 72(4) , pp. 392–402 · doi:10.1111/aji.12276 · PMID:24898804 · W2043358672
article OA: closed CC0 ⤵ 31 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study utilized uterine transplants in mice with varying omega-3 fatty acid levels to demonstrate that systemic omega-3s reduce inflammatory cytokines, Cox-2, and proliferation markers in early endometriosis-like lesions.

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Abstract

PROBLEM: The anti-inflammatory impact of three polyunsaturated fatty acids (3-PUFA) in endometriosis is incompletely understood. The effect of 3-PUFA on endometriosis-like lesions is evaluated as a potential anti-inflammatory treatment target. METHOD OF STUDY: Wild Type (WT) and transgenic Fat-1 mice (high levels of endogenous 3-PUFA) were utilized in a uterine tissue transplant endometriosis model. Experimental donor×host pairs included: WT×WT (WW), WT×Fat-1 (WF), and Fat-1×Fat-1 (FF). Cytokine content (IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IL-17A, IFN-γ, TNF-γ, MCP-1 and RANTES) and immunocellular composition in lesions was determined. RESULTS: Intralesion IL-6 in WF hosts was 99-fold lower than WW hosts (P=0.03). Compared to WW host lesions, Cox-2 levels were decreased in WF [1.5-fold (P=0.02)] and FF [1.2-fold (P=0.01)] host lesions, respectively, and intralesion VEGF expression was increased [1.8-fold; P=0.02 (WF) and 1.5-fold; P=0.01 (FF)]. Lesions in FF hosts demonstrated reduced phosphohistone 3 expression (70%; P=0.03) compared to WW control hosts. CONCLUSIONS: Systemic host 3-PUFA levels influence immune, angiogenic, and proliferative factors implicated in the early establishment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Cytokines Endometriosis Endometriosis Fatty Acids, Omega-3 Animals Anti-Inflammatory Agents B-Lymphocytes B-Lymphocytes Cyclooxygenase 2 Cyclooxygenase 2 Cytokines Cytokines Diet Endometriosis Fatty Acids, Omega-3 Female Inflammation Inflammation Inflammation

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (31)

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