Evaluation of Cyclooxygenase-2 and Prostaglandin E2 Expression in Endometrial Tissue Following 8 Weeks of Swimming Exercise and Omega-3 Intake

Fatemeh Rashidpour, Parvin Farzanegi, Hajar Abbaszadeh
In: Medical Laboratory Journal · 2023 · vol. 17(2) , pp. 26–32 · doi:10.61186/mlj.17.2.26 · W4402608398
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Swimming exercise and omega-3 supplementation, alone or combined, reduced COX-2 and PGE2 expression and reproductive hormone levels in a rat model of endometriosis.

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Abstract

Background and objectives: Endometriosis is a chronic disease that affects approximately 10% of women of reproductive age.The purpose of this study was to evaluate the effects of 8 weeks of swimming exercise and omega-3 supplementation on the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) genes and serum levels of reproductive hormones in the endometrial tissue of a rat model of endometriosis.Methods: In this experimental study, 30 adult Wistar rats were randomly divided into 5 groups of healthy-control, patientcontrol, patient+exercise, patient+omega-3, and patient+omega-3+exercise groups.After the induction of endometriosis, the rats were subjected to 8 weeks of swimming exercise, 5 days a week as well as 2 ml/kg/body weight of omega-3.Data were analyzed using one-way analysis of variance and Tukey post hoc test at the significance level of 0.05.Results: The expression of COX-2 and PGE2 as well as serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels were significantly higher in the patient group compared with the healthy-control group (p0.0001).Exercise and omega-3 supplementation either separately or combined could significantly reduce the expression of both genes and serum levels of LH, FSH, and estradiol (p<0.05).This effect was more profound in the patient+exercise+omega-3 group. Conclusion:The results of the present study indicate that regulating the expression of COX-2 and PGE2 genes as well as serum levels of reproductive hormones through swimming exercise and omega-3 supplementation can improve endometriosis.

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endometriosis

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