Animal models for research on endometriosis

Fuminori Taniguchi, Hermawan Wibisono, Yin Mon Khine, Tasuku Harada
Frontiers in bioscience (Elite edition) · 2020 · vol. 13(1) , pp. 37 · doi:10.2741/871 · PMID:33048775 · W3091996057
article OA: bronze CC0 ⤵ 14 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines murine models of endometriosis, including induced inflammation, gene expression similarities to human disease, and potential drug treatments.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews and outlines murine and primate animal models used to study endometriosis, focusing on how endometriosis-like lesions are generated (e.g., homologous/heterologous transplantation, induced inflammation, and drug-testing paradigms) and what these models reveal about mechanisms such as estrogen/estrogen receptor signaling and gene-expression similarities to human disease. It summarizes that because mice do not spontaneously develop endometriosis, induced models rely on transplantation into the peritoneal cavity, typically with estrogen dependence, and it discusses a major limitation that robust models are scarce and that no single model fully mimics human disease. It also describes an experimental homologous mouse approach using donor uterine tissue transplanted into ovariectomized BALB/c mice with estradiol valerate and notes plans to evaluate SR-16234, parthenolide, and BV6 in this setting. This paper is centrally about endometriosis—reviewing and detailing animal models, including murine lesion induction and drug-testing frameworks, to study its pathogenesis and potential treatments.

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Abstract

Endometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in women. Due to the expense in carrying endometriosis research in primates, other models have been developed for understanding the pathobiology and potential treatment of endometriosis. This includes explanting human endometrial tissues in athymic nude mice or using homologous mouse models. Here, we examine the murine models of endometriosis, the impact of forced induced inflammation on its development, similarities in the gene expression profile in the endometriotic tissues in such models with that seen in human endometriosis, and the drugs that are being used in such models as potential new treatment for endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Animals Endometrium Female Humans Mice

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (56)

Cited by (14)

Source provenance

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