Primate Model Research for Endometriosis

Akiyoshi Yamanaka, Yamanaka A, Kimura F, Fuminori Kimura, Akie Takebayashi, Takebayashi A, Nobuyuki Kita, Kita N, Takahashi K, Kentaro Takahashi, Murakami T, Takashi Murakami
The Tohoku Journal of Experimental Medicine · 2012 · vol. 226(2) , pp. 95–99 · doi:10.1620/tjem.226.95 · PMID:22245765 · W1988645453
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Non-human primate models are superior for endometriosis research due to menstruation and spontaneous disease occurrence, offering valuable insights into pathogenesis and treatment.

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This paper is a 2012 review examining how non-human primate models can be used to study endometriosis, focusing on their effectiveness for investigating pathogenesis, pathophysiology, spontaneous onset, and treatment. It explains that menstrual blood reflux is widely considered crucial to development and highlights a key limitation of common rodent models: rodents do not menstruate and do not develop spontaneous endometriosis, whereas menstruation and spontaneous disease occur in women and some non-human primates. The review summarizes current theories and findings derived from primate research, noting the absence of a curative therapy and frequent recurrence after current treatments. This paper is centrally about endometriosis — it reviews primate model research to address limitations of rodent models and to advance understanding of endometriosis pathogenesis and treatment.

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Abstract

Endometriosis is defined as the existence of endometrial tissue outside the uterine cavity, and it includes a chronic, inflammatory reaction associated with female infertility and pelvic pain. Endometriosis occurs in 7 to 10% of women. Although it has been studied for more than 50 years, the pathogenesis and development of endometriosis are still poorly understood. There is no curative therapy for endometriosis, which often recurs after surgical or medical treatment. There is a consensus that the adverse current of menstrual blood plays a crucial role in the development of endometriosis. This places a major limitation on research using rodent models of endometriosis, although these are still widely employed, because rodents do not menstruate and endometriosis does not occur spontaneously in these animals. In fact, menstruation and spontaneous endometriosis only occur in women and some non-human primates, making models that employ non-human primates the best animal models for research into the pathogenesis, pathophysiology, spontaneous onset, and treatment of endometriosis. This review assesses the effectiveness and potential of the non-human primate models of endometriosis. It also describes the current findings and theories on the pathogenesis of endometriosis that have been obtained by research using non-human primates.
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Review Primate Model Research for Endometriosis 2012 Volume 226 Issue 2 Pages 95-99 Details Abstract Endometriosis is defined as the existence of endometrial tissue outside the uterine cavity, and it includes a chronic, inflammatory reaction associated with female infertility and pelvic pain. Endometriosis occurs in 7 to 10% of women. Although it has been studied for more than 50 years, the pathogenesis and development of endometriosis are still poorly understood. There is no curative therapy for endometriosis, which often recurs after surgical or medical treatment. There is a consensus that the adverse current of menstrual blood plays a crucial role in the development of endometriosis. This places a major limitation on research using rodent models of endometriosis, although these are still widely employed, because rodents do not menstruate and endometriosis does not occur spontaneously in these animals. In fact, menstruation and spontaneous endometriosis only occur in women and some non-human primates, making models that employ non-human primates the best animal models for research into the pathogenesis, pathophysiology, spontaneous onset, and treatment of endometriosis. This review assesses the effectiveness and potential of the non-human primate models of endometriosis. It also describes the current findings and theories on the pathogenesis of endometriosis that have been obtained by research using non-human primates. © 2012 Tohoku University Medical Press Favorites & Alerts Recently viewed articles - About this Journal The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology. - Submitted manuscripts will be screened for plagiarism with Similarity Check (https://www.crossref.org/services/similarity-check/). Announcements from publisher - Subscriptions Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN. Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN. e-mail: [email protected]

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Condition tags

endometriosisinfertility

MeSH descriptors

Disease Models, Animal Endometriosis Menstruation Primates Animals Endometriosis Endometriosis Female Menstruation

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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