Effect of Amygdalin on the treatment and recurrence of endometriosis in an experimental rat study

Hatice Yılmaz Doğru, Cigdem Kunt Isguder, Akgul Arici, Asker Zeki Ozsoy, Ilhan Bahri Delibas, Bulent Cakmak
In: Periodicum Biologorum · 2017 · vol. 119(3) · doi:10.18054/pb.v119i3.4767 · W2766772175
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Amygdalin and leuprolide acetate significantly reduced endometriotic foci volumes in rats compared to saline, with no significant differences in histopathological injury or fibrosis.

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This animal experiment evaluated whether amygdalin or leuprolide acetate affects endometriosis development and recurrence in 30 adult female rats. Endometriosis was induced by implanting endometriotic foci on the peritoneal side of the abdominal wall, with histopathology performed before treatment, followed by 3-week administration of saline (control), amygdalin, or leuprolide, excision of remaining implants, and then estradiol exposure to induce recurrence. Endometriotic focus volumes were significantly lower with amygdalin and leuprolide than with saline, but histopathological injury scores and fibrosis levels did not differ significantly across groups. This paper is centrally about endometriosis — it tests amygdalin’s effects on endometriosis treatment and recurrence in a rat model.

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Abstract

Background: Endometriosis is an aggressive disorder and associated with infertility, pelvic pain and intra-abdominal adhesions in women of reproductive age. Women with endometriosis has the potential risk of recurrence ranging from 21.5% in two years to 50% in five years after recovery period. Therefore, there is a certain requirement for new drugs as an alternative therapy to the current ones.Aim: The aim of the present study is to compare the effects of amygdalin and leuprolide acetate on endometriosis development and recurrence in rats.Study Design: Animal experimentMethods: A total of 30 adult female rats were enrolled. Induction of endometriosis was performed by implanting endometriotic focci on the peritoneal side of the abdominal wall. Before amygdalin or leuprolide acetate treatment one of the implant was removed for histopathological analysis, and rats were randomly divided into three groups. Saline (Group 1), amygdalin (Group 2), and leuprolide acetate (Group 3) were administered for three weeks. After treatment, one of the remaining three implants was excised for histopathological evaluation, and all treatments were terminated. Estradiol was given after the estradiol induction for the recurrence of endometriosis. Rest of the implanted tissues were removed, then all rats were euthanised. The implant volumes, histopathological injury and fibrosis levels were observed.Results: The endometriotic foci volumes in Group 2 and Group 3 were significantly lower than in Group 1 (p = 0.001, p = 0.002, respectively). The histopathological injury scores and fibrosis levels were not significantly different among the groups (p > 0.05).Conclusion: The present study showed that amygdalin has an evident effect in the treatment of endometriosis.
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Background

Endometriosis is an aggressive disorder and associated with infertility, pelvic pain and intra-abdominal adhesions in women of reproductive age. Women with endometriosis has the potential risk of recurrence ranging from 21.5% in two years to 50% in five years after recovery period. Therefore, there is a certain requirement for new drugs as an alternative therapy to the current ones. Aim: The aim of the present study is to compare the effects of amygdalin and leuprolide acetate on endometriosis development and recurrence in rats. Study Design: Animal experiment

Methods

A total of 30 adult female rats were enrolled. Induction of endometriosis was performed by implanting endometriotic focci on the peritoneal side of the abdominal wall. Before amygdalin or leuprolide acetate treatment one of the implant was removed for histopathological analysis, and rats were randomly divided into three groups. Saline (Group 1), amygdalin (Group 2), and leuprolide acetate (Group 3) were administered for three weeks. After treatment, one of the remaining three implants was excised for histopathological evaluation, and all treatments were terminated. Estradiol was given after the estradiol induction for the recurrence of endometriosis. Rest of the implanted tissues were removed, then all rats were euthanised. The implant volumes, histopathological injury and fibrosis levels were observed.

Results

The endometriotic foci volumes in Group 2 and Group 3 were significantly lower than in Group 1 (p = 0.001, p = 0.002, respectively). The histopathological injury scores and fibrosis levels were not significantly different among the groups (p > 0.05).

Conclusion

The present study showed that amygdalin has an evident effect in the treatment of endometriosis. Downloads Published Issue Section License The contents of PERIODICUM BIOLOGORUM may be reproduced without permission provided that credit is given to the journal. It is the author’s responsibility to obtain permission to reproduce illustrations, tables, etc. from other publications.

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endometriosisinfertility

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