Radiation-Induced Endometriosis in Macaca mulatta

John W. Fanton, J W Fanton, J G Golden, John G. Golden
Radiation research · 1991 · vol. 126(2) , pp. 141 · doi:10.2307/3577812 · PMID:1850850 · W2034107951
article OA: closed CC0 ⤵ 49 in-corpus citations
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Abstract

Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy protons, 54%; mixed-energy protons, 73%; X rays, 71%; and electrons, 57%. The incidence of endometriosis in nonirradiated control monkeys was 26%. Monkeys exposed to single-energy protons, mixed-energy protons, and X rays developed endometriosis at a significantly higher rate than control monkeys (chi 2, P less than 0.05). Severity of endometriosis was staged as massive, moderate, and minimal. The incidence of these stages were 65, 16, and 19%, respectively. Observations of clinical disease included weight loss in 43% of the monkeys, anorexia in 35%, space-occupying masses detected by abdominal palpation in 55%, abnormal ovarian/uterine anatomy on rectal examination in 89%, and radiographic evidence of abdominal masses in 38%. Pathological lesions were endometrial cyst formation in 69% of the monkeys, adhesions of the colon in 66%, urinary bladder in 50%, ovaries in 86%, and ureters in 44%, focal nodules of endometrial tissue throughout the omentum in 59%, and metastasis in 9%. Clinical management of endometriosis consisted of debulking surgery and bilateral salpingo-oophorectomy combined in some cases with total abdominal hysterectomy. Postoperative survival rates at 1 and 5 years for monkeys recovering from surgery were 48 and 36%, respectively.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasms, Radiation-Induced Pelvic Neoplasms Protons Space Flight Animals Endometriosis Endometriosis Endometriosis Female Macaca mulatta Neoplasms, Radiation-Induced Neoplasms, Radiation-Induced Pelvic Neoplasms Pelvic Neoplasms Pelvic Neoplasms Survival Rate Whole-Body Irradiation

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