Stimulating effects of 4-chlorodiphenyl ether on surgically induced endometriosis in the mouse

Yang JZ, Jack Yang, J Z Yang, Yagminas A, Al Yagminas, A Yagminas, Warren G. Foster, W G Foster, Foster WG
Reproductive toxicology (Elmsford, N.Y.) · 1997 · vol. 11(1) , pp. 69–75 · doi:10.1016/s0890-6238(96)00198-0 · PMID:9138635 · W2062839205
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This study investigated the impact of 4-chlorodiphenyl ether on surgically induced endometriosis in mice, examining its stimulating effects on the condition.

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Abstract

The objectives of this study were to evaluate the effects of repeated injection of 4-chlorodiphenyl ether (4-CDE) on the survival and growth of endometriotic implants. Endometriosis was surgically induced in adult female B6C3F1 mice (n = 25) after ovariectomy. Seven days later the animals were randomly divided into five groups and treated with vehicle alone (corn oil, control), or 20 micrograms/kg/d estrone (positive control), or 10, 75, or 150 mg/kg/d 4-CDE in vehicle for 28 d. The number and size of the endometriotic cysts were recorded and the cysts were then harvested for histology at necropsy 2 d after the last treatment. There were significantly more cysts formed (P < 0.05) in the 150 mg/kg/d 4-CDE group compared to the vehicle-treated control (60 vs. 8%), but not compared to the estrone-treated positive control (90 vs. 60%). Hepatic enzymes were evaluated to confirm exposure and to further clarify the enzymatic route of 4-CDE biotransformation by the liver. In conclusion, the repeated exposure to 4-CDE increased the survival rates of the endometriotic cysts in the ovariectomized mouse, which suggests that 4-CDE mimics estrogen effects on endometriotic tissues because the endometrial tissues are dependent on estrogenic support for survival.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Phenyl Ethers Water Pollutants, Chemical Animals Body Weight Body Weight Cysts Cysts Cysts Endometriosis Endometriosis Female Halogenated Diphenyl Ethers Mice Mice, Inbred C3H Mice, Inbred C57BL Microsomes, Liver Microsomes, Liver Mixed Function Oxygenases

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References (27)

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