Evaluation of Estrogen Treatment in an Immunodeficient Mouse Endometriosis Model

Sébastien Colette, Sylvie Defrère, Jean-Christophe Lousse, Jean‐Christophe Lousse, Anne Van Langendonckt, Ernest Loumaye, Jacques Donnez
Gynecologic and obstetric investigation · 2009 · vol. 68(4) , pp. 262–268 · doi:10.1159/000240672 · PMID:19776614 · W2029689734
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Estrone treatment did not impact endometriosis development in an immunodeficient mouse model, despite demonstrating estrogen bioactivity and receptor expression in lesions.

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Abstract

BACKGROUND/AIMS: Endometriosis is known to be an estrogen-dependent disease. However, only a few studies have analyzed the effect of estrogen treatment in mice xenotransplanted with human endometrium. The objective of this study was to adapt a previously developed heterologous murine model to the study of estrogens and test the impact of estrone treatment on endometriosis development. METHODS: Human proliferative endometrium was xenotransplanted into the peritoneal cavity of castrated immunodeficient mice. These mice were treated with estrogens by means of subcutaneous estrone-releasing pellets. The effect of estrone on estradiol level, uterine histology and endometriosis development was evaluated after 21 days. RESULTS: Bioactivity of estrone pellets and their metabolization into estradiol were demonstrated. However, there was no impact on endometriosis development (no difference in lesion number, weight, size or fluorescence). This lack of response was not due to absence of estrogen receptor expression, since strong expression was found in all lesions harvested. Surprisingly, castrated nontreated mice presented with lesions showing high proliferative activity, similar to lesions found in treated mice (around 30%). CONCLUSION: The high proliferation observed in lesions recovered from ovariectomized nontreated mice questions the utility of using estrogens in heterologous murine models.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Disease Models, Animal Endometriosis Estrone Immunologic Deficiency Syndromes Adult Animals Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estradiol Estradiol Estrone Estrone Female Fluoresceins Fluorescent Dyes Humans Immunohistochemistry

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (9)

SciLite annotations

chemicals 11
estrogen estrogen estrogen estrone estrone estrone estrone estradiol estrone estradiol estrone
organisms 8
transgenic mice mus sp. human human mus sp. mus sp. mus sp. mus sp.

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License: CC0 · commercial use OK