Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis

Zongjuan Fang, Sijun Yang, John P Lydon, Franco DeMayo, Francesco J. DeMayo, Mitsutoshi Tamura, Bilgin Gurates, Bilgin Gürateş, Serdar E Bulun
Fertility and Sterility · 2004 · vol. 82(3) , pp. 673–678 · doi:10.1016/j.fertnstert.2004.01.048 · PMID:15374713 · W1990762437
article OA: bronze CC0 ⤵ 38 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Progesterone receptor deletion in a mouse model abrogated estradiol's proliferative effects on endometriosis-like lesions, highlighting the receptor's necessity in mediating hormone-driven tissue growth.

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Condition tags

endometriosis

MeSH descriptors

Cell Division Endometriosis Estradiol Receptors, Progesterone Animals Cell Division Cell Division Disease Models, Animal Endometriosis Endometriosis Estradiol Female Mice Mice, Knockout Mice, Transgenic Receptors, Progesterone Receptors, Progesterone Receptors, Progesterone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (38)

Source provenance

europepmc
last seen: 2026-06-24T06:10:11.469335+00:00
openalex
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pubmed
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License: CC0 · commercial use OK