PROGINS receptor gene polymorphism is associated with endometriosis

Fritz Wieser, Wieser F, Christian Schneeberger, Schneeberger C, Dan Tong, Tong D, Dan Cacsire Castillo‐Tong, Clemens Tempfer, Clemens Tempfer, Tempfer C, Huber JC, Johannes C. Huber, Wenzl R, Rene Wenzl, René Wenzl
Fertility and sterility · 2002 · vol. 77(2) , pp. 309–312 · doi:10.1016/s0015-0282(01)02984-3 · PMID:11821088 · W2144765016
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This study investigated the association between the PROGINS receptor gene polymorphism and endometriosis.

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Abstract

ObjectiveTo investigate the association between the 306-base pair insertion polymorphism in intron G of the progesterone receptor (PROGINS) and endometriosis.DesignCase-control study.SettingTertiary care center.Patient(s)Ninety-five white women with surgically diagnosed and histologically confirmed endometriosis and 107 white women without endometriosis (controls).Intervention(s)Determination of PROGINS was performed by polymerase chain reaction and gel electrophoresis. MAIN OUTCOIME MEASURE(S): Frequency and distribution of the PROGINS allele.Result(s)Frequencies of the mutant allele T2 was 0.17 among women with endometriosis and 0.08 among controls (odds ratio, 2.41 [CI, 1.31-4.53]). Homozygosity for allele T2 was present in 3.2% of women with endometriosis and 0.9% of controls.Conclusion(s)PROGINS appears to be associated with endometriosis in white persons.

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Condition tags

endometriosis

MeSH descriptors

DNA Endometriosis Receptors, Progesterone Adult Case-Control Studies DNA DNA DNA Electrophoresis, Agar Gel Endometriosis Female Humans Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Genetic Receptors, Progesterone Statistics, Nonparametric

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