Screening of a panel of steroid-related genes showed polymorphisms of aromatase genes confer susceptibility to advanced stage endometriosis in the Taiwanese Han population

Cheng-Hsuan Wu, Jyuer-Ger Yang, Yu‐Jun Chang, Yu-Jun Chang, Chao-Chin Hsu, Chao‐Chin Hsu, Pao‐Lin Kuo, Pao-Lin Kuo
Taiwanese journal of obstetrics & gynecology · 2013 · vol. 52(4) , pp. 485–492 · doi:10.1016/j.tjog.2013.10.006 · PMID:24411031 · W2013147389
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This study found that polymorphisms in the aromatase gene are associated with an increased risk of advanced stage endometriosis in the Taiwanese Han population.

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Abstract

OBJECTIVE: To establish a multilocus model for studying the effect of steroid-related genes on advanced stage endometriosis. MATERIALS AND METHODS: A total of 121 patients with advanced stage endometriosis and 171 control women were included. Eighteen single-nucleotide polymorphisms (SNPs) from nine genes (HSD17B1, HSD17B2, HSD17B5, HSD17B6, CYP17, CYP19, ERα, ERβ, and PGR) were genotyped using the TaqMan assays. Logistic regression models were used to evaluate the genetic effects, with adjustment for other covariates. RESULTS: Only the presence of the mutant CYP19 (aromatase gene) was associated with a significantly increased risk of endometriosis after adjusting for age, BMI, and parity (p = 0.002, OR = 2.69; 95% CI = 1.44-5.02). No association was ascertained between the other investigated SNPs and endometriosis. CONCLUSION: Polymorphisms of the aromatase gene confer susceptibility to advanced stage endometriosis in the Taiwanese Han population.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Aromatase Asian People Endometriosis Genetic Predisposition to Disease 3-Hydroxysteroid Dehydrogenases 3-Hydroxysteroid Dehydrogenases Adult Aldo-Keto Reductase Family 1 Member C3 Aromatase Asian People Case-Control Studies Endometriosis Endometriosis Estradiol Dehydrogenases Estradiol Dehydrogenases Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor beta Estrogen Receptor beta Female

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