RU486

A A Murphy, Ana A. Murphy, Murphy AA, Castellano PZ, Penny Ž. Castellano, P Z Castellano
Current opinion in obstetrics & gynecology · 1994 · vol. 6(3) , pp. 269–278 · doi:10.1097/00001703-199406000-00012 · PMID:8038415 · W2047982918
article OA: closed CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

RU486, an antiprogestin, has demonstrated efficacy in reducing pelvic pain and endometriosis scores, and decreasing uterine leiomyomata size, suggesting potential therapeutic applications.

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Abstract

More than a decade after the serendipidous discovery of RU486, numerous antiprogestins have been synthesized and studied. Interest in how antiprogestins exert their antagonist effect has led to novel information about the molecular mechanisms of progesterone action. The pivotal role that progesterone plays in reproductive biology has led to research in many areas where a potential role for these compounds may be found in health and disease. RU486 has been shown to relieve pelvic pain associated with endometriosis and to decrease American Fertility Society endometriosis scores. Uterine leiomyomata show a significant reduction in size after administration of RU486 for 3 months. Although much research remains to be carried out, RU486 appears promising as alternative therapies for these diseases.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Leiomyoma Mifepristone Uterine Neoplasms Endometriosis Endometrium Endometrium Female Humans Leiomyoma Mifepristone Mifepristone Progesterone Progesterone Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (16)

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