Association of polymorphisms -1154G/A and -2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women

Qing Liu, Yan Li, Jian Zhao, Jing Zhao, Dong-Lan Sun, Donglin Sun, Ya-Nan Duan, Yanan Duan, Na Wang, Rongmei Zhou, Rong-Miao Zhou, Shan Kang
Human Reproduction · 2009 · vol. 24(10) , pp. 2660–2666 · doi:10.1093/humrep/dep208 · PMID:19531502 · W2127562786
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Polymorphisms at -1154G/A and -2578C/A in the VEGF gene were associated with a decreased risk of endometriosis in Chinese women, particularly the -1154A and -2578A alleles.

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Abstract

BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in the development of endometriosis. The aim of this study was to investigate the association of polymorphisms in the VEGF gene with the susceptibility to endometriosis. METHODS: This study comprised 344 North Chinese women with endometriosis and 360 healthy women without endometriosis recruited as control. Genotyping of the VEGF gene polymorphisms at -460C/T, -1154G/A, -2578C/A and +936C/T were performed by PCR and restriction fragment length polymorphism analysis. RESULTS: No significant difference was found in allele and genotype distributions of the -460C/T, +936C/T polymorphisms between patients and controls. However, the frequencies of -1154G/A, -2578C/A genotype and allele were significantly different between the two groups (all P-value <0.013). The -2578A/A, -1154A/A genotypes were found less frequently in patients with endometriosis compared with controls. The haplotype distributions derived from three polymorphisms (-2578C/A, -1154G/A, -460C/T) differed between the two groups (P = 0.000). CONCLUSIONS: The VEGF-460/-1154/-2578 TGC, CAA, TAA and TAC haplotypes were associated with endometriosis. The -1154A and -2578A alleles may be protective against the development of endometriosis in North Chinese women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Polymorphism, Genetic Vascular Endothelial Growth Factor A Adult Case-Control Studies China Endometriosis Female Gene Frequency Genetic Predisposition to Disease Haplotypes Humans Vascular Endothelial Growth Factor A

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