CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women

S H Juo, Suh‐Hang Hank Juo, Tsu‐Nai Wang, T N Wang, J N Lee, Ming‐Tsang Wu, M T Wu, Changhai Long, C Y Long, E M Tsai, Eing‐Mei Tsai
Human Reproduction · 2006 · vol. 21(6) , pp. 1498–1502 · doi:10.1093/humrep/del033 · PMID:16527884 · W2100204975
article OA: bronze CC0 ⤵ 34 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that a specific homozygous genotype of the COMT gene, encoding low enzyme activity, increased the risk of adenomyosis but not endometriosis in Taiwanese women, while CYP1A1 and CYP17 showed no association with either disease.

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Abstract

BACKGROUND: The aim of the study was to test whether the COMT, CYP1A1 and CYP17 genes influence the risk of developing adenomyosis and endometriosis. METHODS: We conducted two case-control studies, where the cases (n = 198) had either of the two diseases, and controls (n = 312) were disease-free women. For the COMT gene, we selected the G/A nonsynonymous single-nucleotide polymorphism (SNP) that leads to valine-to-methionine (Val/Met) substitution. For the CYP1A1 gene, we used a functional T/C SNP in the 3'-noncoding region, and we genotyped a T/C functional SNP in the 5' region of the CYP17 gene for the present study. Hardy-Weinberg equilibrium was checked in both cases and controls. Logistic regression models were used to evaluate the genetic effect, with adjustment for other covariates. RESULTS: We found that the homozygous COMT genotype that encodes low enzyme activity had an increased risk for adenomyosis with an age-adjusted odds ratio of 3.2 (95% confidence interval 1.3-7.8; P = 0.006). The COMT gene, however, was not associated with endometriosis. Neither the CYP1A1 nor CYP17 genes had any significant association with either of the two diseases. CONCLUSION: The COMT gene significantly influences the risk of adenomyosis but not endometriosis. The present study does not provide evidence to support any of the three genes exerting pleiotropic effects on both diseases.

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Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Catechol O-Methyltransferase Cytochrome P-450 CYP1A1 Endometriosis Polymorphism, Genetic Steroid 17-alpha-Hydroxylase Adult Age Factors Body Mass Index Catechol O-Methyltransferase Cytochrome P-450 CYP1A1 Endometriosis Endometriosis Female Genotype Humans Middle Aged Steroid 17-alpha-Hydroxylase Taiwan

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