Evidence for estrogen synthesis in adenomyotic tissues

Yamamoto T, Takara Yamamoto, T Yamamoto, T Noguchi, Noguchi T, Toshifumi Noguchi, Tamura T, T Tamura, Takaya Tamura, J Kitawaki, Kitawaki J, Jo Kitawaki, Okada H, H Okada, Hiroji Okada
American Journal of Obstetrics and Gynecology · 1993 · vol. 169(3) , pp. 734–738 · doi:10.1016/0002-9378(93)90654-2 · PMID:8372890 · W2028723332
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This paper provides evidence for the synthesis of estrogen within adenomyotic tissues.

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Abstract

ObjectiveTo investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis.Study designAromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatography, and cocrystallization. The effects of danazol on the activity of these enzymes were also examined. Moreover, localization of aromatase in eutopic and ectopic endometrial tissues was immunohistochemically examined with antihuman placental aromatase cytochrome P-450 antibody.ResultsAromatase and estrone sulfatase activities were detected in ectopic endometrium. The activity of these enzymes was significantly suppressed by danazol. In addition, aromatase was immunohistochemically detected in glandular cells of eutopic and ectopic endometrial tissues.ConclusionsThe results suggest that estrogen is synthesized in the eutopic and ectopic endometrial tissues of women with uterine adenomyosis and that it may affect the growth of adenomyosis. Danazol suppressed synthesis of estrogen in vitro.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Estrogens Neoplasms, Hormone-Dependent Uterine Neoplasms Adult Aromatase Aromatase Aromatase Inhibitors Chromatography, Ion Exchange Danazol Danazol Dose-Response Relationship, Drug Endometriosis Endometriosis Estrogens Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Enzymologic Humans Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (50)

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