Effects of a Levonorgestrel-Releasing Intrauterine System on the Expression of Steroid Receptor Coregulators in Adenomyosis

Bo Hyon Yun, Young Eun Jeon, Seok Kyo Seo, Joo Hyun Park, Sun Och Yoon, SiHyun Cho, Young Sik Choi, Byung Seok Lee
Reproductive sciences (Thousand Oaks, Calif.) · 2015 · vol. 22(12) , pp. 1539–1548 · doi:10.1177/1933719115589411 · PMID:26040939 · W1927988832
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This study investigated steroid receptor coregulator expression in adenomyosis and found that a levonorgestrel-releasing intrauterine system altered coregulator levels, suggesting their role in the disease and treatment.

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This study compared expression levels of steroid receptor coregulators in human endometrium from controls and participants with adenomyosis, and assessed whether a levonorgestrel-releasing intrauterine system (LNG-IUS) altered those expression patterns, using immunohistochemistry with H-scores. Steroid receptor coactivators were significantly decreased at the secretory phase in the LNG-IUS group versus other groups, with transcriptional intermediary factor 2 reduced in LNG-IUS compared with both control and untreated adenomyosis during the secretory phase. Amplified in breast cancer 1 was higher in stromal cells of untreated adenomyosis than controls at the secretory phase but was lower in the LNG-IUS group, and nuclear receptor corepressor expression showed a proliferative-to-secretory shift that was reversed by LNG-IUS. The paper notes that the molecular mechanisms underlying LNG-IUS effects on adenomyosis remain unclear, and this is a retrospective expression study, limiting causal inference. This paper is centrally about endometriosis-related disease—specifically adenomyosis—focusing on how LNG-IUS modulates steroid receptor coregulator expression in adenomyosis endometrium.

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YUHASpace Repository 0 937 Cited 0 times in Cited 10 times in Effects of a Levonorgestrel-Releasing Intrauterine System on the Expression of Steroid Receptor Coregulators in Adenomyosis - Authors - Bo Hyon Yun ; Young Eun Jeon ; Byung Seok Lee ; Young Sik Choi ; SiHyun Cho ; Sun Och Yoon ; Joo Hyun Park ; Seok Kyo Seo - Citation - REPRODUCTIVE SCIENCES, Vol.22(12) : 1539-1548, 2015 - Journal Title - REPRODUCTIVE SCIENCES - ISSN - 1933-7191 - Issue Date - 2015 - MeSH - Adenomyosis/drug therapy* ; Adenomyosis/metabolism ; Adenomyosis/pathology ; Adenomyosis/physiopathology ; Adult ; Cell Proliferation ; Endometrium/drug effects* ; Endometrium/metabolism ; Endometrium/pathology ; Endometrium/secretion ; Female ; Humans ; Immunohistochemistry ; Intrauterine Devices* ; Levonorgestrel/administration & dosage* ; Nuclear Receptor Coactivator 2/metabolism* ; Nuclear Receptor Coactivator 3/metabolism* ; Retrospective Studies ; Signal Transduction/drug effects - Keywords - LNG-IUS ; coregulator-related disease ; steroid receptor coregulator - Abstract - Although the pathophysiology of adenomyosis has not been clarified, it is thought to be related to ectopic endometrium, which depends on hormonal regulation. The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective for the medical treatment of adenomyosis. However, the underlying molecular mechanisms by which LNG-IUS ameliorates adenomyosis pathology remain unclear. This study was designed to compare the expression levels of steroid receptor coregulators in human endometrium of control and participants with adenomyosis and to determine whether LNG-IUS modulated their expression. Immunohistochemistry with H-scores was performed. Steroid receptor coactivators were shown to have significantly decreased expressions at the secretory phase in the LNG-IUS group when compared to the other groups. Expression of transcriptional intermediary factor 2 was lower in the LNG-IUS group than in both the control group (P = .015) and the untreated adenomyosis group (P = .019) during the secretory phase. Amplified in breast cancer 1 expression was higher in the stromal cells of the untreated adenomyosis group than in those of the controls (P = .017) during the secretory phase; however, levels were lower in the LNG-IUS group (P = .005). Nuclear receptor corepressor expression increased during the proliferative phase and decreased during the secretory phase in untreated adenomyosis; this pattern was reversed in the control and LNG-IUS groups. Thus, an altered expression of steroid receptor coregulators may play a role in adenomyosis development and treatment. - Appears in Collections: - 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers - Yonsei Authors - Park, Joo Hyun(박주현) Seo, Seok Kyo(서석교) https://orcid.org/0000-0003-3404-0484 Yun, Bo Hyon(윤보현) https://orcid.org/0000-0001-5703-797X Yoon, Sun Ock(윤선옥) https://orcid.org/0000-0002-5115-1402 Lee, Byung Seok(이병석) https://orcid.org/0000-0001-6001-2079 Jeon, Young Eun(전영은) Cho, Si Hyun(조시현) https://orcid.org/0000-0003-2718-6645 Choi, Young Sik(최영식) https://orcid.org/0000-0002-1157-4822 Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrium Intrauterine Devices Levonorgestrel Nuclear Receptor Coactivator 2 Nuclear Receptor Coactivator 3 Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adult Cell Proliferation Endometrium Endometrium Endometrium Female Humans Immunohistochemistry Levonorgestrel Nuclear Receptor Coactivator 2

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