Ovarian steroid receptor expression in endometriosis and in two potential parent epithelia: endometrium and peritoneal mesothelium

Andrew Prentice, A Prentice, Prentice A, B J Randall, Randall BJ, Barbara Randall, Weddell A, A Weddell, A McGill, Andrew C. McGill, McGill A, Linda Henry, Henry L, L Henry, C H Horne, Horne CH, C. H. W. Horne, Eric J. Thomas, Thomas EJ, E J Thomas
Human Reproduction · 1992 · vol. 7(9) , pp. 1318–1325 · doi:10.1093/oxfordjournals.humrep.a137848 · PMID:1479018 · W2248742769
article OA: closed CC0 ⤵ 65 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-09 ⓘ

Ovarian steroid receptor expression was studied in endometrium, peritoneal mesothelium, and endometriosis, finding both receptors in endometrium but not mesothelium, with reduced expression in endometriosis compared to endometrium.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is an oestrogen dependent condition and it is expected that the tissue of origin of endometriosis will express receptors for the ovarian steroids. Two epithelia, endometrium and peritoneal mesothelium, are the potential parent epithelium. Oestrogen and progesterone receptor expression has been studied immunohistochemically in (i) timed endometrial biopsies from 25 normal subjects and 27 patients with endometriosis, (ii) 25 endometriotic biopsies and (iii) 42 peritoneal biopsies. Endometrium but not peritoneal mesothelium expresses both oestrogen and progesterone receptors. No difference in the intensity of staining between endometria of normal subjects compared with the endometria of patients with endometriosis was noted. In paired endometrial and endometriotic biopsies, the intensity of staining for the oestrogen receptor in stromal cells and for the progesterone receptor in both glandular and stromal cells was less in the endometriotic biopsies. These data provide circumstantial evidence for an endometrial origin for endometriosis although quantitative differences exist in receptor expression between endometrium and endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Peritoneum Receptors, Estrogen Receptors, Progesterone Uterine Neoplasms Endometriosis Endometrium Epithelium Epithelium Female Humans Immunohistochemistry Peritoneum Prospective Studies Receptors, Estrogen Receptors, Progesterone Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (50)

Source provenance

europepmc
last seen: 2026-08-21T06:14:13.963979+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:44.647872+00:00
License: CC0 · commercial use OK