Ovarian steroid receptor expression in endometriosis and in two potential parent epithelia: endometrium and peritoneal mesothelium
Observational
OA: closed
CC0
⤵ 65 in-corpus citations
AI-generated summary
Ovarian steroid receptor expression was studied in endometrium, peritoneal mesothelium, and endometriosis, finding both receptors in endometrium but not mesothelium, with reduced expression in endometriosis compared to endometrium.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Endometriosis is an oestrogen dependent condition and it is expected that the tissue of origin of endometriosis will express receptors for the ovarian steroids. Two epithelia, endometrium and peritoneal mesothelium, are the potential parent epithelium. Oestrogen and progesterone receptor expression has been studied immunohistochemically in (i) timed endometrial biopsies from 25 normal subjects and 27 patients with endometriosis, (ii) 25 endometriotic biopsies and (iii) 42 peritoneal biopsies. Endometrium but not peritoneal mesothelium expresses both oestrogen and progesterone receptors. No difference in the intensity of staining between endometria of normal subjects compared with the endometria of patients with endometriosis was noted. In paired endometrial and endometriotic biopsies, the intensity of staining for the oestrogen receptor in stromal cells and for the progesterone receptor in both glandular and stromal cells was less in the endometriotic biopsies. These data provide circumstantial evidence for an endometrial origin for endometriosis although quantitative differences exist in receptor expression between endometrium and endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (50)
- Altered Progesterone Receptor Isoform Expression in Endometrial Cells: A Preliminary Immunohistochemical Study in Endometriosis 2026
- From Retrograde Menstruation to Endometrial Determinism and a Brave New World of "Root Treatment" of Endometriosis: Destiny or a Fanciful Utopia? 2023
- CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis 2023
- Extensive heterogeneity in the expression of steroid receptors in superficial peritoneal endometriotic lesions 2023
- Progesterone Resistance in Endometriosis 2022
- The impact of endometriosis and adenomyosis on the female reproductive system 2022
- Progesterone Actions and Resistance in Gynecological Disorders 2022
- Evaluation the Progesterone and Estrogen Receptor (PR & ESR) Level and Their Role in Medical Treatment of Patients with Endometriosis 2021
- The role of mitogen-activated protein kinase signaling pathway in endometriosis 2021
- Endometriotic lesions 2019
- Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? 2019
- Gene Expression in Endometriosis 2019
- Progesterone Resistance in Endometriosis: an Acquired Property? 2018
- Notch activity mediates oestrogen-induced stromal cell invasion in endometriosis 2018
- Inflammation influences steroid hormone receptors targeted by progestins in endometrial stromal cells from women with endometriosis 2016
- Progesterone Alleviates Endometriosis via Inhibition of Uterine Cell Proliferation, Inflammation and Angiogenesis in an Immunocompetent Mouse Model 2016
- Predisposing and Protective Factors of Endometriosis 2015
- Effects of a Levonorgestrel-Releasing Intrauterine System on the Expression of Steroid Receptor Coregulators in Adenomyosis 2015
- Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants 2015
- The elusive and controversial roles of estrogen and progesterone receptors in human endometriosis 2014
- Sex Steroids and Endometriosis 2014
- Circulating endometrial cells in peripheral blood 2014
- Endometriosis: a new cellular and molecular genetic approach for understanding the pathogenesis and evolutivity 2014
- The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis 2014
- Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis 2011
- Changes in glandular and stromal estrogen and progesterone receptor isoform expression in eutopic and ectopic endometrium following treatment with the levonorgestrel-releasing intrauterine system 2011
- 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis 2010
- Polymorphic (CAG)n repeats in the androgen receptor gene: a risk marker for endometriosis and uterine leiomyomas 2009
- Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue 2009
- Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids 2008
- Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms in women with endometriosis 2008
- Expression und Regulation von Enzymen des Östrogenmetabolismus in humanen Endometriumläsionen kultiviert in der Nacktmaus 2007
- The altered distribution of the steroid hormone receptors and the chaperone immunophilin FKBP52 in a baboon model of endometriosis is associated with progesterone resistance during the window of uterine receptivity 2007
- Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: no association with advanced endometriosis 2007
- Adenomyosis: the pathophysiology of an oestrogen-dependent disease 2006
- A baboon model for endometriosis: implications for fertility 2006
- Subendometrial and intraendometrial blood flow during the menstrual cycle in patients with endometriosis 2005
- Endometriosis: the pathophysiology as an estrogen-dependent disease 2002
- Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women 2002
- Theories of endometriosis 2001
- Progesterone receptor isoform A but not B is expressed in endometriosis 2000
- Reduced proliferation and cell adhesion in endometriosis 2000
- Cellular and genetic constitution of human endometriosis tissues 2000
- Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis1 2000
- Is endometriosis an endometrial disease? 2000
- Current concepts in the pathogenesis of endometriosis 1999
- Physiological and cytogenetic characterization of immortalized human endometriotic cells containing episomal simian virus 40 DNA 1999
- The cyclic pattern of the immunocytochemical expression of oestrogen and progesterone receptors in human myometrial and endometrial layers: characterization of the endometrial-subendometrial unit 1999
- Expression of sex hormone-binding globulin exon VII splicing variant messenger ribonucleic acid in human ovarian endometriosis 1998
- Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol 1998
Source provenance
- europepmc
- last seen: 2026-10-14T06:08:39.101224+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:02:19.201584+00:00
License: CC0
· commercial use OK