Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified–warmed embryo transfer outcomes in women with adenomyosis

Zhou Liang, Liang Z, Liang Zhou, Mingru Yin, Yin M, Ma M, Meng Ma, Wang Y, Yun Wang, Kuang Y, Yanping Kuang
Reproductive biomedicine online · 2019 · vol. 39(1) , pp. 111–118 · doi:10.1016/j.rbmo.2019.03.101 · PMID:31109894 · W2920958364
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Pretreatment with a levonorgestrel-releasing intrauterine system significantly increased ongoing pregnancy, implantation, and clinical pregnancy rates in women with adenomyosis undergoing IVF with vitrified-warmed embryo transfer.

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Abstract

Research questionDoes the use of a levonorgestrel-releasing intrauterine system (LNG-IUS) improve the ongoing pregnancy rate of vitrified-warmed embryo transfer in women with adenomyosis undergoing IVF?DesignThis retrospective study included 358 women with adenomyosis undergoing IVF. Of these, 134 women were enrolled in the LNG-IUS group and another 224 women were in the control group. All women were screened for adenomyosis by transvaginal ultrasound and magnetic resonance imaging (MRI). There was no significant difference in the ages of women, FSH, cause of infertility, body mass index, total dose of gonadotrophin used and number of oocytes collected between the two groups. All comparisons performed were between patients undergoing vitrified-warmed embryo transfer.ResultsStatistical differences were found in the ongoing pregnancy rates (41.8% vs 29.5%, P = 0.017) between the LNG-IUS group and control group. Logistic regression analysis showed that the odds ratio (OR) of ongoing pregnancy was significantly increased with LNG-IUS usage (adjusted OR = 1.628, 95% confidence interval 1.011-2.622). Also, differences were found in implantation rates (32.1% vs 22.1%, P = 0.005) and clinical pregnancy rates (44% versus 33.5%, P = 0.045) between the LNG-IUS group and control group.ConclusionsThe results of this study offer some support for evaluating the effect of pretreatment with LNG-IUS in women with adenomyosis in future randomized controlled trials.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Embryo Transfer Fertilization in Vitro Infertility, Female Intrauterine Devices, Medicated Levonorgestrel Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adult Case-Control Studies China China Cohort Studies Embryo, Mammalian Embryo Transfer Embryo Transfer Female Fertilization in Vitro

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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