Non-contraceptive uses of levonorgestrel-releasing hormone system (LNG-IUS)—A systematic enquiry and overview
This systematic review explores the non-contraceptive applications of the levonorgestrel-releasing intrauterine system (LNG-IUS), analyzing its effectiveness and safety for various gynecological conditions.
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References (100)
- A comparison of flurbiprofen, tranexamic acid, and a levonorgestrel-releasing intrauterine contraceptive device in the treatment of idiopathic menorrhagia via openalex
- A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study via openalex
- Comparison of a levonorgestrel-releasing intrauterine device versus expectant management after conservative surgery for symptomatic endometriosis: a pilot study via openalex
- Comparison of ovarian cyst formation in women using the levonorgestrel‐releasing intrauterine system vs. hysterectomy via openalex
- Development of a miniature, low-dose, frameless intrauterine levonorgestrel-releasing system for contraception and treatment: a review of initial clinical experience via openalex
- Effect of the levonorgestrel-releasing intrauterine system on uterine myomas in a renal transplant patient via openalex
- Efficacy of the levonorgestrel intrauterine system in treating menorrhagia: Actualities and ambiguities via openalex
- Endometrial morphology during hormone replacement therapy with estradiol gel combined to levonorgestrel‐releasing intrauterine device or natural progesterone via openalex
- Endometrial safety with a low-dose intrauterine levonorgestrel-releasing system after 3 years of estrogen substitution therapy via openalex
- Insertion of Mirena after Endometrial Resection in Patients with Adenomyosis via openalex
- Intrauterine administration of levonorgestrel 5 and 10 μg/24 hours in perimenopausal hormone replacement therapy via openalex
- Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery via openalex
- Medical treatment of a grossly enlarged adenomyotic uterus with the levonorgestrel-releasing intrauterine system via openalex
- Pre and post-operative medical therapy for endometriosis surgery via openalex
- Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications via openalex
- The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex
- The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease via openalex
- The Mirena(R) levonorgestrel system via openalex
- Therapeutic Use of the LNG IUS, and Counseling via openalex
- Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device via openalex
- Treatment of menorrhagia with a novel 'frameless' intrauterine levonorgestrel-releasing drug delivery system: a pilot study via openalex
- Treatment of menorrhagia with the levonorgestrel intrauterine system versus endometrial resection via openalex
- Treatment of primary and secondary dysmenorrhea with a novel 'frameless' intrauterine levonorgestrel-releasing drug delivery system: a pilot study via openalex
- Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis via openalex
- W2002100432 via openalex
- W2002242365 via openalex
- W2007314409 via openalex
- W2014670555 via openalex
- W2015015693 via openalex
- W2015496453 via openalex
- W2017512719 via openalex
- W2017875018 via openalex
- W2019632662 via openalex
- W2021595766 via openalex
- W2027206018 via openalex
- W2030869506 via openalex
- W2031357322 via openalex
- W2031785143 via openalex
- W2033128963 via openalex
- W2035440290 via openalex
- W2037729051 via openalex
- W2038587859 via openalex
- W2038846760 via openalex
- W2040706253 via openalex
- W2041983304 via openalex
- W2043601943 via openalex
- W2047111383 via openalex
- W2048255951 via openalex
- W2048256030 via openalex
- W2051230413 via openalex
- W2051702417 via openalex
- W2053624386 via openalex
- W2053998452 via openalex
- W2059919214 via openalex
- W2060103518 via openalex
- W2060296314 via openalex
- W2065160252 via openalex
- W2069642788 via openalex
- W2079088665 via openalex
- W2080656085 via openalex
- W2089215866 via openalex
- W2091560484 via openalex
- W2092026322 via openalex
- W2101734337 via openalex
- W2117722672 via openalex
- W2119931006 via openalex
- W2123134517 via openalex
- W2125950103 via openalex
- W2129543398 via openalex
- W2131967409 via openalex
- W2132061576 via openalex
- W2133286624 via openalex
- W2137349921 via openalex
- W2140370772 via openalex
- W2140895197 via openalex
- W2147795078 via openalex
- W2152367884 via openalex
- W2155352577 via openalex
- W2155524358 via openalex
- W2156829341 via openalex
- W2156896195 via openalex
- W2159861206 via openalex
- W2163145424 via openalex
- W2166028293 via openalex
- W2170200160 via openalex
- W2170722449 via openalex
- W2204279972 via openalex
- W2293013867 via openalex
- W2294874207 via openalex
- W2302500786 via openalex
- W2322639718 via openalex
- W2327042378 via openalex
- W2338305153 via openalex
- W2409575779 via openalex
- W2418241203 via openalex
- W2471274913 via openalex
- W2515721699 via openalex
- W4200472726 via openalex
- W4210999290 via openalex
- W4239892039 via openalex
Cited by (33)
- Real-world outcomes of the levonorgestrel-releasing intrauterine system for heavy menstrual bleeding or dysmenorrhea in Japanese patients: A prospective observational study (J-MIRAI) 2022
- Endometriosis in Adolescent Girls 2020
- A multicenter, randomized, placebo-controlled, double-blind, comparative study of dienogest at 1 mg/day in patients with primary and secondary dysmenorrhea 2020
- Long‐term use of dienogest for the treatment of primary and secondary dysmenorrhea 2020
- La périménopause 2019
- Effect of pretreatment with a levonorgestrel-releasing intrauterine system on IVF and vitrified–warmed embryo transfer outcomes in women with adenomyosis 2019
- Evaluation of the efficacy, safety, and clinically recommended dose of dienogest in the treatment of primary dysmenorrhea: a randomized, double-blind, multicenter, placebo-controlled study 2019
- Abnormal Uterine Bleeding in Adolescent Women 2018
- Comparative analysis of changes in MR imaging of pre and post intrauterine progesterone implants in adenomyosis cases 2015
- Endometrial Synovial-like Metaplasia Associated With Levonorgestrel-releasing Intrauterine System 2015
- Acute urticaria as a side effect of the Mirena® (levonorgestrel-releasing intrauterine system): a case report 2014
- Different Bleeding Patterns with the Use of Levonorgestrel Intrauterine System: Are They Associated with Changes in Uterine Artery Blood Flow? 2014
- Effects of the levonorgestrel-releasing intrauterine system on urinary symptoms in patients with adenomyosis 2013
- The effects of levonorgestrel intra-uterine system on adenomyosis and endometriosis: A three year follow up study 2012
- Hysterectomy and levonorgestrel-releasing intrauterine system in the treatment of menorrhagia : a 10-year randomized comparative trial 2012
- The efficacy of the levonorgestrel-releasing intrauterine system in perimenopausal women with menorrhagia or dysmenorrhea 2011
- Levonorgestrel intra-uterine system as a treatment option for complex endometrial hyperplasia 2011
- Noncontraceptive Uses of Hormonal Contraception 2011
- Innovations in conservative endometriosis treatment: an updated review. 2011
- Hormonal contraceptives and endometriosis/adenomyosis 2010
- Non-contraceptive applications of the levonorgestrel intrauterine system 2010
- Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications 2010
- Hormone therapy for endometriosis and surgical menopause 2009
- An investigation of basic science and clinical research methodologies to benefit clinical practice 2009
- Levonorgestrelį išskiriančios gimdos spiralės vartojimas ginekologijoje 2009
- New Developments in Medical Management of Endometriosis 2009
- Intrauterine progestins, progesterone antagonists, and receptor modulators: a review of gynecologic applications 2009
- Review of the safety, efficacy and patient acceptability of the levonorgestrel-releasing intrauterine system 2008
- The Levonorgestrel-releasing Intrauterine System: An Updated Review of the Contraceptive and Noncontraceptive Uses 2007
- Hormonal treatments for adenomyosis 2007
- Medicated intrauterine systems for treatment of endometriosis-associated pain 2006
- Too soon, too late, too often, too seldom? 2006
- The anatomy and neurophysiology of pelvic pain 2006
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- europepmc
- last seen: 2026-06-13T06:22:48.782012+00:00
- openalex
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- pubmed
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