Treatment of menorrhagia with the levonorgestrel intrauterine system versus endometrial resection

O Istre, Olav Istre, Birgitta Trolle, B Trolle
Fertility and sterility · 2001 · vol. 76(2) , pp. 304–309 · doi:10.1016/s0015-0282(01)01909-4 · PMID:11476777 · W2129635652
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This study investigated the efficacy of the levonorgestrel intrauterine system compared to endometrial resection for treating menorrhagia.

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Abstract

OBJECTIVE: Treatment of menorrhagia with levonorgestrel intrauterine system (LNG IUS) and transcervical resection. DESIGN: An open, therapeutic, randomized study. SETTING: Central county hospital specializing in hysteroscopy. PATIENT(S): Two parallel groups of 30 subjects each. INTERVENTION(S): Thirty patients had a LNG IUS inserted within the first 7 days of menses; 29 patients underwent endometrial resection. MAIN OUTCOME MEASURE(S): A 12-month follow-up of menstrual blood loss and adverse events were evaluated. RESULT(S): LNG IUS group: 13 patients reported one or more pelvic adverse events, bleeding disorders (n = 6), abdominal pain (n = 4), breast tenderness (n = 3), headache, acne (n = 2), and mood changes (n = 1). Six patients discontinued treatment because of irregular bleeding (n = 3), pain (n = 2), and acne (n = 1). In both groups, general feeling of genital health increased with Visual Analogue Scale score. Nine patients reported adverse events. This included pelvic pain indicating inflammation (n = 4), bleeding (n = 3), vaginitis (n = 1), and ulceration (n = 1). Treatment success at 12 months was achieved in 20 (67%) of the 30 patients in the LNG IUS group and in 26 (90%) of the 29 patients in the transcervical resection group. Adverse events were more often reported in the LNG IUS group. CONCLUSION(S): Both treatments effectively reduced the menstrual blood loss. Furthermore, the LNG IUS treatment is reversible and has no operative hazards.

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MeSH descriptors

Endometrium Levonorgestrel Menorrhagia Menorrhagia Adult Climacteric Dysmenorrhea Dysmenorrhea Endometrium Female Humans Hysteroscopy Intrauterine Devices Intrauterine Devices Levonorgestrel Levonorgestrel Menorrhagia

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