The effects of the levonorgestrel intrauterine system (Mirena coil) on endometrial morphology
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This study reviewed endometrial specimens from 75 women with the Mirena coil, documenting decidualization, glandular atrophy, and stromal inflammation as common morphological features.
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Abstract
AIMS: The Mirena coil is a levonorgestrel releasing intrauterine device that is in widespread use. This study aims to document the endometrial morphology associated with this device. METHODS: Endometrial specimens from 75 women with the Mirena coil were reviewed and the histological features detailed. RESULTS: Morphological features found in most of the endometria were decidualisation of stroma (72 of 75 cases), atrophy of endometrial glands (65 of 75 cases), a surface papillary pattern (38 of 75 cases), and a stromal inflammatory cell infiltrate (59 of 75 cases). Additional common histological features were the presence of foci of stromal myxoid change (29 of 75 cases) and stromal haemosiderin pigment (24 of 75 cases). Reactive atypia of surface glands, glandular metaplastic changes, stromal necrosis, and stromal calcifications were found in small numbers of cases. CONCLUSION: The endometrial features are characteristic and relatively constant and are in keeping with the effects of both a progestogenic compound and a mechanical device. Pathologists should be aware of these histological features because the Mirena coil is in widespread use.
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References (16)
- Pregnancy associated endometriosis with pronounced stromal myxoid change via openalex
- Treatment of menorrhagia with the levonorgestrel intrauterine system versus endometrial resection via openalex
- doi:10.1067/mob.2002.122130 via openalex
- doi:10.1016/s0140-6736(85)91513-2 via openalex
- doi:10.1002/cncr.10435 via openalex
- doi:10.1097/00042192-200111000-00006 via openalex
- doi:10.1093/humrep/13.5.1218 via openalex
- doi:10.1097/00000478-199408000-00013 via openalex
- doi:10.1111/j.1600-0560.1993.tb01257.x via openalex
- doi:10.1016/s0140-6736(00)03204-9 via openalex
- doi:10.1016/s0029-7844(97)00297-4 via openalex
- doi:10.1097/00004347-198609000-00005 via openalex
- doi:10.1136/bmj.316.7145.1671 via openalex
- doi:10.1016/s0015-0282(99)00162-4 via openalex
- doi:10.1136/dtb.2001.391185 via openalex
- doi:10.1016/0010-7824(77)90001-4 via openalex
Cited by (15)
- Markers of human endometrial hypoxia can be detected <i>in vivo</i> and <i>ex vivo</i> during physiological menstruation 2021
- Benign Diseases of the Endometrium 2018
- Endometrial Synovial-like Metaplasia Associated With Levonorgestrel-releasing Intrauterine System 2015
- A review of the endometrial histologic effects of progestins and progesterone receptor modulators in reproductive age women 2015
- <i>In silico</i>,<i>in vitro</i>and<i>in vivo</i>analysis identifies a potential role for steroid hormone regulation of FOXD3 in endometriosis-associated genes 2015
- Die Wirkung von hCG auf die Dezidualisierung ektoper endometrialer Läsionen als therapeutischer Ansatz zur Behandlung der Endometriose 2014
- LNG-IUS treatment of non-atypical endometrial hyperplasia in perimenopausal women: a randomized controlled trial 2013
- Effects of levonorgestrel-releasing intrauterine system and T380A intrauterine copper device on dysmenorrhea and days of bleeding in women with and without adenomyosis 2012
- Clinical outcome of levonorgestrel intra-uterine system in idiopathic menorrhagia. 2011
- The efficacy of the levonorgestrel-releasing intrauterine system in perimenopausal women with menorrhagia or dysmenorrhea 2011
- The effectiveness of levonorgestrel releasing intrauterine system in the treatment of endometrial hyperplasia in Korean women 2010
- Decidualization Attenuates the Contractility of Eutopic and Ectopic Endometrial Stromal Cells: Implications for Hormone Therapy of Endometriosis 2009
- Response of the Uterus to Medication: Hysteroscopic Implications 2009
- Intrauterine release of progesterone antagonist ZK230211 is feasible and results in novel endometrial effects: a pilot study 2007
- Correlation between endometrial histology, microvascular density and calibre, matrix metalloproteinase-3 and bleeding pattern in women using a levonorgestrel-releasing intrauterine system 2004
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