Adenomyosis and Reproduction: a Narrative Review

Nicola Berlanda, Agnese Donati, Francesco Fedele, Dhouha Dridi, Giulia Emily Cetera, Paolo Vercellini
In: Current Obstetrics and Gynecology Reports · 2022 · vol. 11(3) , pp. 198–224 · doi:10.1007/s13669-022-00336-5 · W4224304465
review OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Adenomyosis negatively impacts reproductive outcomes, with GnRH agonist pre-treatment showing potential benefits and conservative surgery yielding similar pregnancy rates but increased live births.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This narrative review investigated reproductive outcomes in infertile women with adenomyosis undergoing assisted reproductive technologies (ART) or conservative surgical treatment, compiling 23 ART studies (3791 women with adenomyosis and 6841 controls) and 11 studies of prior conservative surgery (961 women). Across ART comparisons with controls, adenomyosis was associated with lower pregnancy rate (39.4% vs 49.8%) and live birth rate (29.9% vs 42.6%) and higher miscarriage rate (26.3% vs 15.3%), while implantation rates were similar; the review also reports risks including placenta previa, placenta accreta, uterine rupture, and postoperative adhesions. For GnRH agonist pretreatment, some included studies reported improved pregnancy, miscarriage, or live birth outcomes, while the magnitude of live-birth benefit was noted as needing clearer definition; conservative surgery showed similar pregnancy rates to non-surgery but with an increase in live births. This paper is centrally about endometriosis and adenomyosis — it is focused on adenomyosis’s reproductive impact in ART and conservative surgical contexts.

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adenomyosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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