The impact of adenomyosis on the outcome of IVF–embryo transfer

D. Mavrelos, Dimitrios Mavrelos, Holland TK, Tom K Holland, Tom Holland, O'Donovan O, Oliver O'Donovan, Khalil M, Mohamed Khalil, Ploumpidis G, George Ploumpidis, Davor Jurkovic, D. Jurkovic, Jurkovic D, Khalaf Y, Yakoub Khalaf
Reproductive biomedicine online · 2017 · vol. 35(5) , pp. 549–554 · doi:10.1016/j.rbmo.2017.06.026 · PMID:28802706 · W2739813802
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This study investigated the relationship between adenomyosis and IVF-embryo transfer outcomes, finding that adenomyosis negatively impacts pregnancy and implantation rates.

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Abstract

Our study examined the impact of adenomyosis on the chance of clinical pregnancy after IVF and embryo transfer (IVF-ET). This was a prospective multicentre study from April 2013 to October 2015. We included 375 women with history of infertility who attended for a 3D scan prior to IVF-ET. A total of 150/375 (40.0%, 95% confidence interval [CI] 35.2-45.0) women had clinical pregnancy. Women with any feature of adenomyosis had a lower clinical pregnancy rate (21/72 [29.2%, 95% CI 18.6-39.6] versus 129/303 [42.6%, 95% CI 37.1-48.2], P = 0.044, relative risk (RR) 0.68 [95% CI 0.47-1.00]). Logistic regression selected an adenomyosis score of 4 or higher as an independent predictor of clinical pregnancy (odds ratio [OR] 0.35 [95% CI 0.15-0.82]). Estimated probability of clinical pregnancy decreased from 42.7% (95% CI 37.1-48.3) for women with no adenomyosis features to 22.9% (95% CI 13.4-32.6) for those with four and 13.0% (95% CI 2.2-23.9) for those with all seven. Women with adenomyosis have lower clinical pregnancy rate after IVF-ET. Condition severity expressed as a number of morphological features on ultrasound scan increases the magnitude of the effect.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Embryo Transfer Fertilization in Vitro Pregnancy Rate Adenomyosis Adenomyosis Adult Female Humans Infertility, Female Pregnancy Prospective Studies

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