The impact of adenomyosis on the outcome of IVF-embryo transfer

D. Mavrelos, Dimitrios Mavrelos, Holland TK, Tom K Holland, Tom Holland, O'Donovan O, Oliver O'Donovan, Khalil M, Mohamed Khalil, Ploumpidis G, George Ploumpidis, Davor Jurkovic, D. Jurkovic, Jurkovic D, Khalaf Y, Yakoub Khalaf
Reproductive BioMedicine Online · 2017 · vol. 35(5) , pp. 549–554 · doi:10.1016/j.rbmo.2017.06.026 · PMID:28802706 · W2739813802
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This study investigated the relationship between adenomyosis and IVF-embryo transfer outcomes, finding that adenomyosis negatively impacts pregnancy and implantation rates.

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Abstract

Our study examined the impact of adenomyosis on the chance of clinical pregnancy after IVF and embryo transfer (IVF-ET). This was a prospective multicentre study from April 2013 to October 2015. We included 375 women with history of infertility who attended for a 3D scan prior to IVF-ET. A total of 150/375 (40.0%, 95% confidence interval [CI] 35.2-45.0) women had clinical pregnancy. Women with any feature of adenomyosis had a lower clinical pregnancy rate (21/72 [29.2%, 95% CI 18.6-39.6] versus 129/303 [42.6%, 95% CI 37.1-48.2], P = 0.044, relative risk (RR) 0.68 [95% CI 0.47-1.00]). Logistic regression selected an adenomyosis score of 4 or higher as an independent predictor of clinical pregnancy (odds ratio [OR] 0.35 [95% CI 0.15-0.82]). Estimated probability of clinical pregnancy decreased from 42.7% (95% CI 37.1-48.3) for women with no adenomyosis features to 22.9% (95% CI 13.4-32.6) for those with four and 13.0% (95% CI 2.2-23.9) for those with all seven. Women with adenomyosis have lower clinical pregnancy rate after IVF-ET. Condition severity expressed as a number of morphological features on ultrasound scan increases the magnitude of the effect.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Embryo Transfer Embryo Transfer Fertilization in Vitro Fertilization in Vitro Pregnancy Rate Pregnancy Rate Adenomyosis Adenomyosis Adenomyosis Adult Adult Female Female Humans Humans Infertility, Female Infertility, Female Pregnancy Pregnancy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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