The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages

Kelton P Tremellen, Kelton Tremellen, Tremellen KP, Peter Russell, Russell P
Journal of reproductive immunology · 2011 · vol. 93(1) , pp. 58–63 · doi:10.1016/j.jri.2011.12.001 · PMID:22209314 · W2034819767
article OA: closed CC0 ⤵ 80 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the distribution of immune cells and macrophages in the endometria of women experiencing recurrent reproductive failure, specifically focusing on cases of adenomyosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Adenomyosis, a condition usually associated with multiparity, is not generally seen as a cause of infertility. However, recent studies have reported a reduction in IVF implantation rates and a link with miscarriage, suggesting that adenomyosis may interfere with successful implantation. To investigate this hypothesis, the clinical records and laboratory results, which routinely include immunohistochemical examination of a late luteal phase endometrial biopsy for leukocytes, were retrospectively reviewed for 64 women with implantation failure and who previously had been screened for the presence of adenomyosis by pelvic MRI. The presence of either diffuse or "adenomyoma" type of adenomyosis was associated with a marked increase (p=0.004) in the density of macrophages and natural killer cells in the endometrial stroma, compared to those women with mild focal adenomyosis or no disease. These findings point to an immunological mechanism by which adenomyosis might interfere with successful embryo implantation.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

MeSH descriptors

Embryo Implantation Endometriosis Endometrium Infertility, Female Macrophages Embryo Implantation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Infertility, Female Infertility, Female Macrophages Magnetic Resonance Imaging Parity Parity Pelvis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (37)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-21T06:11:07.228698+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:23.388809+00:00
unpaywall
last seen: 2026-07-21T06:50:27.635823+00:00
License: CC0 · commercial use OK