Physiopathologie de l’adénomyose : une énigme non résolue

Mathilde Bourdon, Bourdon M, M. Bourdon, Santulli P, Piétro Santulli, P Santulli, Louis Marcellin, L Marcellin, Marcellin L, C Maignien, Maignien C, Chloé Maignien, L Maitrot-Mantelet, Lorraine Maitrot‐Mantelet, Charles Chapron, Chapron C, C. Chapron
Gynecologie, obstetrique, fertilite & senologie · 2021 · vol. 50(2) , pp. 182–188 · doi:10.1016/j.gofs.2021.10.005 · PMID:34656788 · W3207750610
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review explores the unresolved physiopathology of adenomyosis, discussing potential mechanisms and diagnostic challenges.

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Abstract

Adenomyosis is a chronic benign uterine disease characterized by the presence of endometrial glands and stroma within the myometrium. It is a heterogeneous disease, presenting various clinical forms, depending on the location of the ectopic lesions within the myometrium. Adenomyosis can be responsible for several symptoms such as dysmenorrhea, abnormal uterine bleeding and/or infertility. Its pathophysiology is a real conundrum and several theories have been proposed: development of adenomyosis lesion could initiate de novo from Mullerian rests or from stem cells. Moreover, multiple factors could be involved in initiating lesions, including specific hormonal, immune and/or genetic changes. The objective of this review is to provide an update on adenomyosis pathophysiology, in particular on the various theories proposed concerning the invasion of the myometrium by endometrial cells and the inducing mechanisms, and to study the link between the physiopathology, the symptoms and the medical treatments.

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Condition tags

dysmenorrhea

MeSH descriptors

Adenomyosis Adenomyosis Uterine Diseases Uterine Diseases Dysmenorrhea Endometrium Female Humans Myometrium Myometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (72)

Source provenance

europepmc
last seen: 2026-08-06T06:07:45.168820+00:00
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License: CC0 · commercial use OK