Uterine peristalsis-induced stresses within the uterine wall may sprout adenomyosis

Sivan Shaked, Ariel J Jaffa, Dan Grisaru, David Elad
Biomechanics and modeling in mechanobiology · 2014 · vol. 14(3) , pp. 437–444 · doi:10.1007/s10237-014-0614-4 · PMID:25217062 · W1970475851
article OA: closed CC0 ⤵ 25 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

A 2D finite element model simulating uterine peristalsis revealed that decreased wavelength and increased frequency of pressure waves generate high stress concentrations at the endometrial-myometrial interface, potentially causing tissue lesions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The paper studies, using a conceptual 2D finite-element model implemented in ADINA software, how uterine wall stress distributions respond to intrauterine sinusoidal pressure waves of different frequencies and wavelengths. It finds that shorter pressure-wave wavelengths produce high stress concentrations near the inner uterine cavity, that higher pressure-wave frequencies create high stress gradients, and that at the menstrual phase the highest stresses occur at the endometrial–myometrial interface. The major caveat is that this is a conceptual computational model of uterine pressure activity rather than direct experimental or clinical measurement of tissue injury. This paper is centrally about adenomyosis — it tests a “tissue injury and repair” mechanism by showing pressure-induced mechanical stresses at the endometrial–myometrial interface that could promote adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Myometrium Peristalsis Stress, Physiological Adenomyosis Female Humans Myometrium Peristalsis

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References (38)

Cited by (26)

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