Immune-inflammatory predictors of the pelvic pain syndrome associated with adenomyosis

M R Orazov, Mekan R. Orazov, V E Radzinsky, Radzinsky VE, О. М. Носенко, E N Nosenko, M B Khamoshina, Khamoshina MB, М.Б. Хамошина, A O Dukhin, Dukhin AO, А. О. Духин, М. G. Lebedeva, M G Lebedeva
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 33(sup1) , pp. 44–46 · doi:10.1080/09513590.2017.1399696 · PMID:29264987 · W2778263708
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This study found significantly higher CD68 expression in macrophages within ectopic endometrium and perivascular myometrium in women with painful adenomyosis compared to those with painless adenomyosis.

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Abstract

The aim of the study was the analysis of immune inflammatory processes in the development of the pelvic pain syndrome associated with adenomyosis. For morphological examination were used 54 fragments of the myometrium obtained from patients after hysterectomy with pelvic pain on a background of diffuse adenomyosis of II-III degree, and 20 patients with painless form of adenomyosis. The identification of the macrophages distribution was held by means of an immune-hysto-chemical analysis of MAT (monoclonal antibody) for CD68. (Clone PG-M1, 'Diagnostic BioSystems', USA). The results of the study showed a significantly higher expression of CD68 (49.3 ± 2.3 vs. 21.2 ± 1.7 units. p < .01) in patients with painful adenomyosis form in areas of the ectopic endometrium, in the perivascular regions of the myometrium, as compared to those areas in women with painless group. We assume that these factors increase neurogenic inflammation and sensitivity of nociceptors in myometrium, activation of peripheral nerve fibers and, can act as triggers of the pelvic pain syndrome associated with adenomyosis.

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Condition tags

chronic_pelvic_painadenomyosis

MeSH descriptors

Adenomyosis Myometrium Pelvic Pain Adenomyosis Adenomyosis Antigens, CD Antigens, CD Antigens, Differentiation, Myelomonocytic Antigens, Differentiation, Myelomonocytic Biomarkers Biomarkers CD68 Molecule Female Humans Inflammation Inflammation Lymphocytes Lymphocytes Macrophages Macrophages

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (21)

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