Aberrantly expressed long noncoding RNAs in the eutopic endometria of patients with uterine adenomyosis

Jian Fa Jiang, Jiang JF, Sun AJ, Ai Jun Sun, Xue W, Wei Xue, Yan Deng, Deng Y, Yan Fang Wang, Wang YF
European journal of obstetrics, gynecology, and reproductive biology · 2016 · vol. 199 , pp. 32–37 · doi:10.1016/j.ejogrb.2016.01.033 · PMID:26896594 · W2269546088
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This study identified specific long noncoding RNAs that are abnormally expressed in the uterine endometria of patients diagnosed with adenomyosis.

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Abstract

ObjectiveAdenomyosis is a common gynecologic disease. Alterations in the eutopic endometria might play an important role in the pathogenesis of adenomyosis. Long non-coding RNA (lncRNA) represents key regulators of gene expression. Our goal was to identify differentially expressed long noncoding RNA and messenger RNA (mRNA) in the eutopic endometria of subjects with adenomyosis on a genome-wide scale.Study designThe expression level of lncRNAs and mRNAs in the eutopic endometria from women with adenomyosis and from that of normal control subjects were detected by Affymetrix Human Transcriptome Array 2.0. Bioinformatics analysis was done for further investigation. Three up-regulated and three down-regulated lncRNAs were randomly chosen for validation by quantitative real-time polymerase chain reaction.ResultsA total of 165 lncRNAs and 612 mRNAs were aberrantly expressed in the eutopic endometria of subjects with adenomyosis. Pathway analysis indicated that 40 pathways corresponded to up-regulated transcripts and 39 pathways corresponded to downregulated transcripts. A list of genes that might play roles in the pathogenesis of adenomyosis were produced by comparing the difference between co-expression networks. Expression of six chosen lncRNAs was validated by quantitative real-time polymerase chain reaction.ConclusionThis study show for the first time that the lncRNA expression profile is altered in women with adenomyosis and provides new biological foundations for further mechanistic studies in this enigmatic disorder.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrium RNA, Long Noncoding Adenomyosis Adenomyosis Adenomyosis Adult Down-Regulation Endometrium Endometrium Female Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis Signal Transduction Signal Transduction Up-Regulation

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