Decoding the multifactorial etiology of chronic endometritis

Gene Jiing‐Yun You, Guanying You, Shuyi Yu, Meng Liu, Lianghui Diao, Ruochun Lian, Yuye Li
In: Placenta · 2025 · vol. 180 , pp. 118–127 · doi:10.1016/j.placenta.2025.09.007 · PMID:40957733 · W4414105629
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⚙ AI-generated summary by claude@2026-06, 2026-06-21 ⓘ

This paper investigates the complex factors contributing to the development of chronic endometritis.

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Abstract

Chronic endometritis (CE) is a persistent inflammatory disorder of the endometrium, typically marked by abnormal plasma cell infiltration. It is closely associated with adverse pregnancy outcomes. The pathogenesis of CE involves a complex interplay of both infectious and non-infectious factors. Infectious etiologies include ascending infection pathways, pelvic infection pathways, sexually transmission, hematogenous infection pathways and special infections, while non-infectious factors encompass uterine structural pathology, autoimmune disorders and iatrogenic factors. Considering the multifactorial etiology of CE, adopting a personalized management approach that integrates both microbial and immune factors may enhance pregnancy outcomes for CE women.

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disambig:endometritis

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