Presence of hydrosalpinx correlated to endometrial inflammatory response in vivo

Alan B. Copperman, Valerie Wells, Martha Luna, Tamara Kalir, B. Sandler, Tanmoy Mukherjee
In: Fertility and Sterility · 2006 · vol. 86(4) , pp. 972–976 · doi:10.1016/j.fertnstert.2006.02.113 · PMID:17027363 · W2107043620
article OA: bronze CC0 ⤵ 12 in-corpus citations
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This study investigated the link between hydrosalpinx and the endometrial inflammatory response in living organisms, finding a correlation between the two conditions.

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Abstract

ObjectiveTo evaluate and compare the inflammatory response and mediators in the endometrium of patients with hydrosalpinges compared with normal controls.DesignRetrospective case-control study.SettingUrban medical center.Patient(s) and intervention(s)Hysterectomy samples were identified as being affected by hydrosalpinx or salpingitis (n = 30) and were age-matched with control samples (n = 30).InterventionsFallopian tube and endometrial slides were analyzed for leukocytes and immunohistochemical techniques performed for cytokines (interleukin-2 [IL-2]).Main outcome measure(s)Evaluate and compare the endometrial inflammatory response (leukocytes and cytokines) from samples affected and non-affected by hydrosalpinx and salpingitis.Result(s)Examination of tubal and endometrial slides with hydrosalpinx demonstrated a statistically significant increase in the number of overall inflammatory cells. High-intensity immunohistochemical staining for IL-2 was demonstrated in 7.4% of controls versus 65% of cases.Conclusion(s)A defined, identifiable, local response to hydrosalpingeal fluid has been demonstrated in the endometrium. This response consists of statistically significant elevations of leukocytes and IL-2. An inflammatory endometrial response may be an independent contributor to the decreased reproductive outcome observed in patients with hydrosalpinges.

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